BIOMAT Database Logo BIOMAT Database Logo

Mice lacking L1 have reduced CGRP fibre in-growth into spinal transection lesions. 2007

Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Pain Management and Research Center, Department of Anesthesiology, Academic Hospital Maastricht, and European Graduate School of Neuroscience (EURON), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. r.deumens@np.unimaas.nl

Repair strategies for spinal cord injury often focus on promoting regeneration of injured axons and stimulating subsequent functional recovery. Although many of these strategies have proven their merits, less is known about potential unwanted side-effects, such as sprouting of nociceptive CGRP immunoreactive axons, which may bring about pain-related behavior. Sprouting of CGRP axons into lesion sites spontaneously occurs after spinal cord injury (SCI). Using L1-deficient mice we show a reduction of such CGRP growth response. This reduction was specific for CGRP axons since the overall neurofilament positive fibre in-growth into the spinal lesion site was not affected. Our results may have important implications on the development and assessment of repair strategies that should not only stimulate functional recovery, but also prevent the development of pain or autonomic dysreflexia.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009412 Nerve Fibers Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM. Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D009475 Neurons, Afferent Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM. Afferent Neurons,Afferent Neuron,Neuron, Afferent
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001369 Axons Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body. Axon
D013119 Spinal Cord Injuries Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.). Myelopathy, Traumatic,Injuries, Spinal Cord,Post-Traumatic Myelopathy,Spinal Cord Contusion,Spinal Cord Laceration,Spinal Cord Transection,Spinal Cord Trauma,Contusion, Spinal Cord,Contusions, Spinal Cord,Cord Contusion, Spinal,Cord Contusions, Spinal,Cord Injuries, Spinal,Cord Injury, Spinal,Cord Laceration, Spinal,Cord Lacerations, Spinal,Cord Transection, Spinal,Cord Transections, Spinal,Cord Trauma, Spinal,Cord Traumas, Spinal,Injury, Spinal Cord,Laceration, Spinal Cord,Lacerations, Spinal Cord,Myelopathies, Post-Traumatic,Myelopathies, Traumatic,Myelopathy, Post-Traumatic,Post Traumatic Myelopathy,Post-Traumatic Myelopathies,Spinal Cord Contusions,Spinal Cord Injury,Spinal Cord Lacerations,Spinal Cord Transections,Spinal Cord Traumas,Transection, Spinal Cord,Transections, Spinal Cord,Trauma, Spinal Cord,Traumas, Spinal Cord,Traumatic Myelopathies,Traumatic Myelopathy
D015740 Calcitonin Gene-Related Peptide A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator. Calcitonin Gene-Related Peptide I,Calcitonin Gene-Related Peptide II,alpha-CGRP,alpha-Calcitonin Gene-Related Peptide,beta-CGRP,beta-Calcitonin Gene-Related Peptide,Calcitonin Gene Related Peptide,Calcitonin Gene Related Peptide I,Calcitonin Gene Related Peptide II,Gene-Related Peptide, Calcitonin,alpha Calcitonin Gene Related Peptide,beta Calcitonin Gene Related Peptide

Related Publications

Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Brain development in mice lacking L1-L1 homophilic adhesion.
April 2004, The Journal of cell biology,
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus.
November 1998, The Journal of clinical investigation,
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Electro-acupuncture upregulates CGRP expression after rat spinal cord transection.
December 2012, Neurochemistry international,
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
CGRP expression increases in the ventral horn rostral to spinal cord transection.
November 1996, Neuroreport,
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Reduced spinal cord sensitization to C-fibre stimulation in mice over-expressing galanin.
May 2003, The European journal of neuroscience,
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Reduced alcohol consumption in mice lacking preprodynorphin.
October 2006, Alcohol (Fayetteville, N.Y.),
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Mice lacking L1 cell adhesion molecule have deficits in locomotion and exhibit enhanced corticospinal tract sprouting following mild contusion injury to the spinal cord.
April 2006, The European journal of neuroscience,
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Mice lacking Mrp1 have reduced testicular steroid hormone levels and alterations in steroid biosynthetic enzymes.
May 2010, General and comparative endocrinology,
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Mice lacking have reduced signs of metabolic syndrome and non-alcoholic fatty liver disease.
April 2018, The Journal of biological chemistry,
Ronald Deumens, and Miriam Lübbers, and Robby J P Jaken, and Matthijs F L Meijs, and Rogier M Thurlings, and Wiel M M Honig, and Melitta Schachner, and Gary A Brook, and Elbert A J Joosten
Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors.
January 2013, PloS one,
Copied contents to your clipboard!