Ototoxicity of ototopical drops--an update. 2007

David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
The Otology Group of Vanderbilt, Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Medical Center East S. Tower 7209, 1215 21st Avenue South, Nashville, TN 37232-5555, USA. david.haynes@vanderbilt.edu

Various topical preparations are widely used for treating external otitis, acute otitis media with perforation, post-tympanostomy tube otorrhea, and chronic suppurative otitis media. Solutions and suspensions that enter the middle ear through a perforated tympanic membrane can reach the inner ear by crossing through the round window membrane. The safety of various components of otic solutions used in this way, particularly aminoglycosides, corticosteroids, solvents, and preservatives, has been questioned in light of their ototoxic potential. The authors' objective is to review the literature discussing the safety of commonly used classes of otic preparations in settings in which the constituents can access the middle and inner ear in high concentrations and discuss their clinical experience with ototoxicity and experience with medical-legal issues.

UI MeSH Term Description Entries
D010034 Otitis Media with Effusion Inflammation of the middle ear with a clear pale yellow-colored transudate. Middle Ear Effusion,Otitis Media, Secretory,Otitis Media, Serous,Ear Effusion, Middle,Ear Effusions, Middle,Effusion, Middle Ear,Effusions, Middle Ear,Middle Ear Effusions,Secretory Otitis Media,Serous Otitis Media
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000287 Administration, Topical The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example. Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001424 Bacterial Infections Infections by bacteria, general or unspecified. Bacterial Disease,Bacterial Infection,Infection, Bacterial,Infections, Bacterial,Bacterial Diseases
D017410 Practice Guidelines as Topic Works about directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery. Clinical Guidelines as Topic,Best Practices,Best Practice
D018058 Tympanic Membrane Perforation A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition. Eardrum Perforation,Tympanic Membrane Rupture,Membrane Perforation, Tympanic,Membrane Rupture, Tympanic,Perforation, Eardrum,Rupture, Tympanic Membrane

Related Publications

David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
March 2004, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
January 2001, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
February 1997, The Journal of otolaryngology,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
January 1987, The American journal of otology,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
May 1991, Antimicrobial agents and chemotherapy,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
January 1972, Transactions - American Academy of Ophthalmology and Otolaryngology. American Academy of Ophthalmology and Otolaryngology,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
March 1993, The American journal of otology,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
January 1980, Journal francais d'oto-rhino-laryngologie; audiophonologie, chirurgie maxillo-faciale,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
March 1993, The American journal of otology,
David S Haynes, and John Rutka, and Michael Hawke, and Peter S Roland
June 1994, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
Copied contents to your clipboard!