BIOMAT Database Logo BIOMAT Database Logo

IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis. 2007

Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
Immunologie des Leishmanioses, Institut Pasteur de la Guyane, 97306 Cayenne, French Guiana.

Cytokines are increasingly recognized as important components of the cellular immune responses to intracellular pathogens. In this study, we analyzed the production of TGF-beta, IL-10 and IFN-gamma by PBMC of unexposed naïve subjects and LCL patients after stimulation with live Leishmania guyanensis (L.g.). We demonstrated that IFN-gamma is produced in controls and LCL patients, IL-10 only in LCL patients and TGF-beta only in naïve subjects. Furthermore, in naive subjects, neutralization of TGF-beta induced IL-10 production. IL-10 produced in naïve subjects when TGF-beta is neutralized or in LCL patients did not modify the IFN-gamma production but inhibit reactive nitrogen species production. Analysis of the phenotype of IL-10 producing cells in naive subjects when TGF-beta is neutralized clearly showed that they are memory CD45RA- CD8+ T cells. In LCL patients, IL-10 producing cells are both CD45RA- CD4 and CD8+ T cells. The role of these IL-10 producing CD8+ T cells in the development of the diseases should be carefully evaluated.

UI MeSH Term Description Entries
D007156 Immunologic Memory The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus. Immune Memory,Immunological Memory,Memory, Immunologic,Immune Memories,Immunologic Memories,Immunological Memories,Memory, Immune,Memory, Immunological
D007897 Leishmaniasis, Mucocutaneous A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms. Leishmaniases, Mucocutaneous,Mucocutaneous Leishmaniases,Mucocutaneous Leishmaniasis
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016753 Interleukin-10 A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein. IL-10,CSIF-10,Cytokine Synthesis Inhibitory Factor,IL10,Interleukin 10
D017493 Leukocyte Common Antigens High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain two FIBRONECTIN TYPE III DOMAINS and possess cytoplasmic protein tyrosine phosphatase activity, which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. Leukocyte common antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons. Antigens, CD45,CD45 Antigens,CD45R Antigens,CD45RA Antigens,CD45RO Antigens,Protein Tyrosine Phosphatase, Receptor Type, C,2H4 Antigens,B220 Antigen,B220 Antigens,CD45 Antigen,CD45R0 Antigens,CD45RB Antigens,CD45RCAntigens,L-CA Antigens,Leukocyte Common Antigen,T200 Antigens,Antigen, B220,Antigen, CD45,Antigen, Leukocyte Common,Antigens, 2H4,Antigens, B220,Antigens, CD45R,Antigens, CD45R0,Antigens, CD45RA,Antigens, CD45RB,Antigens, CD45RO,Antigens, L-CA,Antigens, Leukocyte Common,Antigens, T200,L CA Antigens
D018334 Leishmania guyanensis A parasitic hemoflagellate of the subgenus Leishmania viannia that infects man and animals and causes mucocutaneous leishmaniasis (LEISHMANIASIS, MUCOCUTANEOUS). Transmission is by Lutzomyia sandflies. Leishmania (Viannia) guyanensis,Leishmania (Viannia) panamensis,Leishmania braziliensis guyanensis,Leishmania guyanensis guyanensis,Leishmania brasiliensis guyanensis,Leishmania viannia guyanensis,Leishmania viannia panamensis,Leishmania brasiliensis guyanenses,Leishmania braziliensis guyanenses,Leishmania guyanenses,Leishmania guyanensis guyanenses,Leishmania viannia guyanenses,Leishmania viannia panamenses,brasiliensis guyanensis, Leishmania,braziliensis guyanenses, Leishmania,guyanenses, Leishmania,guyanenses, Leishmania brasiliensis,guyanenses, Leishmania braziliensis,guyanenses, Leishmania guyanensis,guyanensis guyanensis, Leishmania,guyanensis, Leishmania brasiliensis,guyanensis, Leishmania braziliensis,guyanensis, Leishmania guyanensis,guyanensis, Leishmania viannia,panamenses, Leishmania viannia,viannia guyanenses, Leishmania,viannia guyanensis, Leishmania,viannia panamenses, Leishmania,viannia panamensis, Leishmania

Related Publications

Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
Immunomodulating role of IL-10-producing B cells in Leishmania amazonensis infection.
December 2018, Cellular immunology,
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption.
September 2003, The Journal of allergy and clinical immunology,
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions.
June 1994, Current opinion in immunology,
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
Expansion of IL-10-producing CD4+ and CD8+ T cells in fixed drug eruption.
January 2006, Dermatology (Basel, Switzerland),
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
Regulatory roles of IL-10-producing human follicular T cells.
August 2019, The Journal of experimental medicine,
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
IL-23 drives pathogenic IL-17-producing CD8+ T cells.
May 2009, Journal of immunology (Baltimore, Md. : 1950),
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
IFN-gamma-producing CD45RA+CD8+ and IL-10-producing CD45RA-CD4+ T cells generated in response to LACK in naive subjects never exposed to Leishmania.
February 2002, European journal of immunology,
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection.
December 2006, Hepatology (Baltimore, Md.),
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
Type I IFN-producing CD4 Valpha14i NKT cells facilitate priming of IL-10-producing CD8 T cells by hepatocytes.
February 2007, Journal of immunology (Baltimore, Md. : 1950),
Eliane Bourreau, and Catherine Ronet, and Pierre Couppié, and Dominique Sainte-Marie, and Fabienne Tacchini-Cottier, and Pascal Launois
Leishmania (Viannia) guyanensis infection, Austria.
September 2012, Emerging infectious diseases,
Copied contents to your clipboard!