Biomaterial Database

Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form. 2007

N M Gowekar, and V V Pande, and A V Kasture, and A R Tekade, and J G Chandorkar

Department of Pharmaceutics, Maharashtra Institute of Pharmacy, Paud Road, Kothrud, Pune-3.

Fixed dose combination tablets containing ambroxol HCl and cetirizine HCl are clinically used as mucolytic and antiallergic. Several spectrophotometric and HPLC methods have been reported for simultaneous estimation of these drugs with other drugs. The drugs individually and in mixture obeys Beer's law over conc. range 1.2-4.4 microg/mL for cetirizine HCL and for ambroxol HCL 15-52 microg/mL at all five sampling wavelengths (correlation coeff. well above 0.995). The mean recoveries from tablet by standard addition method were 100.18% (+/-2.4) and 100.66 % (+/-2.31). The present work reports simple, accurate and precise spectrophotometric methods for their simultaneous estimation from tablet dosage form.

UI	MeSH Term	Description	Entries
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D005100	Expectorants	Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.	Expectorant,Mucolytic,Mucolytic Agent,Mucolytic Agents,Mucolytics,Agent, Mucolytic,Agents, Mucolytic
D000551	Ambroxol	A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.	Bromhexine Metabolite VIII,4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexanol,AMBROPP,Abrohexal,Ambril,Ambro-Puren,Ambrobeta,Ambrofur,Ambrohexal,Ambrolitic,Ambrolös,Ambroten,Ambroxin,Ambroxocompren,Bisolvon AM,Bronchopront,Bronchowern,Broxol,Contac Husten-Trunk,Dinobroxol,Duramucal,Ebromin,Expeflen,Expit,Farmabroxol,Flavamed,Frenopect,Gelopol,Larylin Husten-Löser,Lasolvan,Mibrox,Motosol,Muco-Fips,Mucosolvan,Mucotablin,NA-872,Pect Hustenlöser,Pulmonal S,Pädiamuc,Ringelheimer Pulmonal,Sekretovit,Surbronc,Therapin Hustenlöser,stas-Hustenlöser,AM, Bisolvon,Ambro Puren,AmbroPuren,Contac Husten Trunk,Contac HustenTrunk,Hustenlöser, Pect,Hustenlöser, Therapin,Larylin Husten Löser,Larylin HustenLöser,Metabolite VIII, Bromhexine,Muco Fips,MucoFips,NA 872,NA872,Pulmonal, Ringelheimer,stas Hustenlöser,stasHustenlöser
D013056	Spectrophotometry, Ultraviolet	Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Ultraviolet Spectrophotometry
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet
D017332	Cetirizine	A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.	Aller-Tec,(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic Acid,Alerlisin,Cetalerg,Ceterifug,Ceti TAD,Ceti-Puren,CetiLich,Cetiderm,Cetidura,Cetil von ct,Cetirigamma,Cetirizin AL,Cetirizin AZU,Cetirizin Basics,Cetirizine Dihydrochloride,Cetirlan,P-071,Reactine,Virlix,Voltric,Zetir,Zirtek,Zyrtec,Dihydrochloride, Cetirizine,P 071,P071
D018926	Anti-Allergic Agents	Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)	Anti-Allergic,Anti-Allergic Agent,Anti-Allergy Drug,Antiallergic,Antiallergic Agent,Antiallergic Drug,Anti-Allergics,Anti-Allergy Drugs,Antiallergic Agents,Antiallergic Drugs,Antiallergics,Antiallergy Agents,Agent, Anti-Allergic,Agent, Antiallergic,Agents, Anti-Allergic,Agents, Antiallergic,Agents, Antiallergy,Anti Allergic,Anti Allergic Agent,Anti Allergic Agents,Anti Allergics,Anti Allergy Drug,Anti Allergy Drugs,Drug, Anti-Allergy,Drug, Antiallergic,Drugs, Anti-Allergy,Drugs, Antiallergic