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The trophoblast cells which contact with maternal tissue express HLA class I either weakly or not at all. This phenomenon is beneficial for the protection of the fetus from immunological rejection by the mother. However, the mechanisms of reduced expression of HLA class I are unexplained. Therefore, we utilized choriocarcinoma cells to analyse the suppressive mechanisms to HLA class I expression in trophoblasts. In this paper we reported the heterogeneity of HLA class I expression in five choriocarcinoma cell lines. The levels of surface HLA class I molecules correlate approximately with mRNA of HLA class I heavy chain, and all choriocarcinoma cells produce moderate amounts of surface and secreted beta 2 microglobulin. It was also found that interferon gamma upregulates HLA class I molecules and mRNA in two choriocarcinoma cell lines, NUC1 and HCCM5.
M Kato, and
K Ohashi, and
F Saji, and
A Wakimoto, and
O Tanizawa
January 1986,
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M Kato, and
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A Wakimoto, and
O Tanizawa
August 1980,
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M Kato, and
K Ohashi, and
F Saji, and
A Wakimoto, and
O Tanizawa
August 1986,
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M Kato, and
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A Wakimoto, and
O Tanizawa
October 1984,
Proceedings of the National Academy of Sciences of the United States of America,
M Kato, and
K Ohashi, and
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A Wakimoto, and
O Tanizawa
February 1985,
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M Kato, and
K Ohashi, and
F Saji, and
A Wakimoto, and
O Tanizawa
January 1986,
Nihon Sanka Fujinka Gakkai zasshi,
M Kato, and
K Ohashi, and
F Saji, and
A Wakimoto, and
O Tanizawa
February 1990,
Journal of immunology (Baltimore, Md. : 1950),
M Kato, and
K Ohashi, and
F Saji, and
A Wakimoto, and
O Tanizawa
January 1992,
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M Kato, and
K Ohashi, and
F Saji, and
A Wakimoto, and
O Tanizawa
June 1990,
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M Kato, and
K Ohashi, and
F Saji, and
A Wakimoto, and
O Tanizawa
September 1992,
Transplantation,
