-transparent.png){kind=logo}
Plasma haloperidol (HAL) and reduced HAL (RHAL) concentrations were measured in 113 Chinese schizophrenic patients. Daily doses of HAL ranged from 8 to 65 mg. Samples were obtained under steady-state conditions and drawn 10-12 hours after the bedtime dose and before the morning dose. In all, 313 blood samples were collected. Multiple samples were obtained at the same doses in 63 patients and at two or three different doses in 31 patients. HAL and RHAL concentrations were assayed by high performance liquid chromatography. Interpatient variation in plasma HAL levels at a given dosage was up to sixfold. However, there was a high positive correlation between plasma levels and daily dosages with the equation of HAL plasma level (ng/ml) = 0.88 x dosage (mg/day) -0.56 or 46.0 x dosage (mg/day/kg) + 0.28. The expected values are about 15-55% higher than those obtained from non-Chinese patients as reported in the literature. The RHAL/HAL ratios were dose-dependent. The greater the dose used, the higher the ratio. An upper therapeutic limit of plasma HAL level is suggested to be 25 ng/ml, which can be achieved at dosages about 30 mg/day in most Chinese patients. Based upon the dose-dependent increase in RHAL/HAL ratios, the importance of RHAL in determining the therapeutic benefit of HAL treatment is discussed.
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
July 1995,
Psychiatry research,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
June 1994,
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
September 1997,
Psychiatry research,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
November 1987,
Biological psychiatry,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
June 1984,
Journal of clinical psychopharmacology,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
February 1990,
Psychiatry research,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
July 1989,
Biological psychiatry,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
January 1990,
Psychopharmacology,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
January 1993,
Progress in neuro-psychopharmacology & biological psychiatry,
W H Chang, and
H G Hwu, and
H Y Lane, and
S K Lin, and
T Y Chen, and
H Chen, and
H L Wei, and
W L Lin, and
H N Lin
February 1995,
Journal of clinical pharmacology,
