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OBJECTIVE L-Carnitine is an essential cofactor in the mitochondrial transfer of fatty acids, and it is also a scavenger of free radicals in mammalian tissues. The aim of the study was to determine the effect of L-carnitine on chronic restraint stress-induced gastric mucosal injury. METHODS Wistar rats were applied restraint stress (1 h/day) and L-carnitine (50 mg/kg) for 21 days. The lesion index, prostaglandin E(2) and mucus content, lipid peroxidation, superoxide dismutase, and catalase activity in gastric mucosa were evaluated. RESULTS Chronic restraint stress increased the lesion index, lipid peroxidation, and superoxide dismutase activity in gastric mucosa, and it decreased prostaglandin E(2) and mucus content. L-Carnitine treatment prevented the stress-induced increase in lesion index, lipid peroxidation and a stress-induced decline in prostaglandin E(2), and mucus content in gastric mucosa, but it increased catalase activity. CONCLUSIONS L-Carnitine prevents the occurrence of lesion by strengthening the gastric mucosal barrier and by reducing lipid peroxidation against the harmful effects of chronic restraint stress.
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
January 2006,
Cell biochemistry and function,
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
January 1994,
Experimental gerontology,
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
December 2019,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
November 2014,
Canadian journal of physiology and pharmacology,
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
January 1987,
Drugs under experimental and clinical research,
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
November 2023,
Alcohol (Fayetteville, N.Y.),
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
December 1986,
Infusionstherapie und klinische Ernahrung,
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
October 1983,
The Journal of nutrition,
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
August 2011,
Basic & clinical pharmacology & toxicology,
V Nimet Izgüt-Uysal, and
Mehmet Bülbül, and
Ruken Tan, and
Narin Derin, and
Ismail Ustünel, and
Aysel Ağar, and
Piraye Yargiçoğlu
September 2011,
Acta anaesthesiologica Scandinavica,
