BIOMAT Database Logo BIOMAT Database Logo

The circadian rhythm of osteoprotegerin and its association with parathyroid hormone secretion. 2007

F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
Department of Diabetes and Endocrinology, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, United Kingdom. drfrankjoseph@yahoo.co.uk

BACKGROUND Osteoclast resorptive activity, which is known to demonstrate circadian rhythmicity, is regulated by various endocrine hormones and cytokines. PTH suppresses osteoprotegerin (OPG), a regulator of osteoclast activity that has recently been shown to have a circadian rhythm in healthy controls. We studied the differences in the relationship between PTH, OPG, and type I collagen C-telopeptide (betaCTX) over a 24-h period in premenopausal women, elderly postmenopausal women, and elderly men. METHODS Hourly peripheral venous blood samples were obtained from 18 healthy non-osteoporotic volunteers: premenopausal women (n = 6; mean age, 30.2 +/- 2.2 yr), postmenopausal women (n = 6; mean age, 68.2 +/- 2.6 yr), and elderly men (n = 6; mean age, 68.2 +/- 2.3 yr). Plasma PTH (1-84), OPG, betaCTX, and calcium were measured on all samples. Cosinor analysis was performed to analyze the circadian rhythm parameters. Cross-correlation analysis was used to determine the relationship between the time series of the variables. RESULTS The 24-h mean PTH, OPG, and betaCTX concentrations were significantly higher in postmenopausal women as compared with premenopausal women and elderly men (P < 0.001). Significant circadian rhythms were observed for PTH (P < 0.05), OPG (P < 0.05), and betaCTX (P < 0.001) in all subjects. PTH secretion was characterized by two peaks in premenopausal women and elderly men and by a sustained increase in PTH concentration in postmenopausal women. OPG secretion was circadian with a daytime increase and nocturnal decrease, and a greater percent decrease in OPG secretion was observed in the postmenopausal women between 1600 and 2400 h. OPG secretion was inversely related to PTH (r = -0.4) and betaCTX (r = -0.6) secretion over a 24-h period. CONCLUSIONS This report confirms a circadian rhythm for circulating OPG. The nocturnal decline in circulating OPG is greater in postmenopausal women as compared with premenopausal women and elderly men. Altered PTH secretion may contribute to the OPG secretory pattern in postmenopausal women resulting in increased nocturnal bone resorption.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010281 Parathyroid Hormone A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates. Natpara,PTH (1-84),PTH(1-34),Parathormone,Parathyrin,Parathyroid Hormone (1-34),Parathyroid Hormone (1-84),Parathyroid Hormone Peptide (1-34),Hormone, Parathyroid
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003720 Densitometry The measurement of the density of a material by measuring the amount of light or radiation passing through (or absorbed by) the material. Densitometries
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
Circadian rhythm and pulsatility of parathyroid hormone secretion in man.
December 1992, Clinical endocrinology,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
The circadian rhythm of intact parathyroid hormone-(1-84): temporal correlation with prolactin secretion in normal men.
December 1990, The Journal of clinical endocrinology and metabolism,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
[Circadian rhythm of adenohypophyseal hormone secretion in women with obesity].
January 1983, Akusherstvo i ginekologiia,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
The physiology of the circadian rhythm of parathyroid hormone and its potential as a treatment for osteoporosis.
July 2004, Current opinion in nephrology and hypertension,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
[Circadian rhythm of growth hormone secretion in Turner's syndrome].
January 1985, Endokrynologia Polska,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
Parathyroid hormone decreases endothelial osteoprotegerin secretion: role of protein kinase A and C.
January 2009, American journal of physiology. Renal physiology,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
Circadian rhythm of luteinizing hormone secretion in the ovariectomized rat implanted with oestradiol.
November 1977, The Journal of endocrinology,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
A circadian rhythm of luteinizing hormone secretion in ovariectomized rats.
February 1968, The American journal of physiology,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
Circadian secretion rhythm of GLP-1 and its influencing factors.
January 2022, Frontiers in endocrinology,
F Joseph, and B Y Chan, and B H Durham, and A M Ahmad, and S Vinjamuri, and J A Gallagher, and J P Vora, and W D Fraser
Tissue-engineered parathyroid gland and its regulatory secretion of parathyroid hormone.
October 2020, Journal of tissue engineering and regenerative medicine,
Copied contents to your clipboard!