Biomaterial Database

Roles of axonal voltage-dependent ion channels in damaged peripheral nerves. 2007

Tufan Mert

University of Cukurova, Faculty of Medicine, Department of Biophysics, 01330 Balcali, Adana, Turkey. tufanmert@yahoo.com

Ion channels are fundamental to the correct functioning of nerves. A high density of Na(v) channels at nodes of Ranvier is crucial for generating sufficient local current to initiate a self-regenerating action potential. K(v)7 (KCNQ) channels are also functional components of nodes of Ranvier and contribute to the repolarization of the action potential. Paranodes underlying the paranodal loops have no channels whereas K(v)1.1 and K(v)1.2 channels cluster at juxtaparanodes. The disruption of the normal balance of different channels causes the inappropriate nerve activity that underlies a variety of nervous system diseases. Axonal voltage-dependent channels, nodal Na(v) and juxtaparanodal K(v) channels disperse after the nerve injury and reorganize with regeneration.

UI	MeSH Term	Description	Entries
D010525	Peripheral Nerves	The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.	Endoneurium,Epineurium,Perineurium,Endoneuriums,Epineuriums,Nerve, Peripheral,Nerves, Peripheral,Perineuriums,Peripheral Nerve
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001369	Axons	Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.	Axon
D015222	Sodium Channels	Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.	Ion Channels, Sodium,Ion Channel, Sodium,Sodium Channel,Sodium Ion Channels,Channel, Sodium,Channel, Sodium Ion,Channels, Sodium,Channels, Sodium Ion,Sodium Ion Channel
D059348	Peripheral Nerve Injuries	Injuries to the PERIPHERAL NERVES.	Peripheral Nerve Injury,Nerve Injuries, Peripheral,Nerve Injury, Peripheral
D024642	Potassium Channels, Voltage-Gated	Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.	Voltage-Gated Potassium Channels,Kv Potassium Channels,Potassium Channel, Voltage-Gated,Voltage-Gated K+ Channels,Voltage-Gated Potassium Channel,K+ Channels, Voltage-Gated,Potassium Channel, Voltage Gated,Potassium Channels, Kv,Potassium Channels, Voltage Gated,Voltage Gated K+ Channels,Voltage Gated Potassium Channel,Voltage Gated Potassium Channels