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Cutaneous responses to vaccinia in individuals with previous smallpox vaccination. 2007
Eric L Simpson, and
Michelle Hercher, and
Erika K Hammarlund, and
Matthew W Lewis, and
Mark K Slifka, and
Jon M Hanifin
Department of Dermatology, Oregon Health and Science University, Center for Health and Healing (CH16D), 3303 SW Bond Ave, Portland, OR 97239-4501, USA. caroccic@ohsu.edu
The durability of immune responses to smallpox vaccine is a subject of considerable debate. We compared cutaneous vaccinia responses in patients vaccinated in the distant past with vaccine-naïve individuals using serial close-up photographs. The previously vaccinated group had a significantly reduced time course and milder cutaneous reactions. Vaccinated individuals appear to maintain clinically detectable immunity against vaccinia for at least 20 years after smallpox vaccination.
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Medical history,
