BACKGROUND Psoriasis is a common, chronic, inflammatory and proliferative skin disease associated with abnormal lipid metabolism. Previous studies have demonstrated that patients with psoriasis may have an increased risk of occlusive vascular disease. OBJECTIVE The aim of this study was to determine lipid profile in Iranian patients with psoriasis. METHODS A cross-sectional study was performed in 30 patients with approved psoriasis diagnosis attending the Dermatology Outpatient Department at Sina Hospital, Hamedan, Iran and 30 matched healthy individuals. Fasting blood sugar (FBS), triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were measured using standard enzymatic method. The psoriasis activity was evaluated by psoriasis area and severity index (PASI Index). RESULTS FBS levels were higher in patients with psoriasis diagnosis but the differences were not significant (P-value = 0.284). There were no significant differences between serum levels of triglyceride and cholesterol in two groups. There were no differences in lipoproteins (HDL, LDL, VLDL) compared with control subjects. (P-value > 0.05) PASI Index and lipid profile did not have any significant correlation. The correlation between duration of disease and LDL were significant (P-value = 0.033). CONCLUSIONS Lipid profile in Iranian patients with psoriasis did not differ compared with control-matched subjects.