Alterations in dendritic morphology of hippocampal neurons in adult rats after neonatal administration of N-omega-nitro-L-arginine. 2007

Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
Laboratorio de Neuropsiquiatría, Instituto de Fisiología, Universidad Autónoma de Puebla, Puebla, México.

The dendritic length and dendritic-spine density of the pyramidal neurons of the prefrontal cortex and the CA1 hippocampus of rats using the nonselective nitric oxide synthase inhibitor N-omega-nitro-L-arginine (L-NNA) at different postnatal day (P) periods of the brain development (P1-P3, P4-P6, and P7-P9) were assessed using Golgi-Cox staining after puberty (P60). At P4-P6, the L-NNA treatment produced a significant decrease of the dendritic length and dendritic-spine density of the pyramidal cells of the CA1 hippocampus. In addition, the dendritic length of the pyramidal neurons of the CA1 hippocampus decreased because of the L-NNA treatment at P1-P3. These data suggest that during a specific step in the development of the brain, the nitric oxide levels may play a critical role in the morphological modifications of the pyramidal neurons of the CA1 hippocampus at postpubertal age.

UI MeSH Term Description Entries
D008297 Male Males
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D003712 Dendrites Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS. Dendrite
D004791 Enzyme Inhibitors Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. Enzyme Inhibitor,Inhibitor, Enzyme,Inhibitors, Enzyme
D005260 Female Females
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000367 Age Factors Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time. Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000831 Animals, Newborn Refers to animals in the period of time just after birth. Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D016622 Silver Staining The use of silver, usually silver nitrate, as a reagent for producing contrast or coloration in tissue specimens. Silver Nitrate Staining,Nitrate Staining, Silver,Staining, Silver,Staining, Silver Nitrate

Related Publications

Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
September 2006, Synapse (New York, N.Y.),
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
December 1995, European journal of pharmacology,
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
November 1993, Gastroenterology,
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
January 2001, Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica,
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
April 2008, Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology,
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
April 1996, American journal of therapeutics,
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
April 1997, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
June 1997, Neuroscience letters,
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
July 2004, Biochemical pharmacology,
Julio César Morales-Medina, and Alejandro Mejorada, and Alejandra Romero-Curiel, and Gonzalo Flores
March 1994, European journal of pharmacology,
Copied contents to your clipboard!