Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax. 2007

Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Súo Paulo, Brasil.

In previous immuno-epidemiological studies of the naturally acquired antibody responses to merozoite surface protein-1 (MSP-1) of Plasmodium vivax, we had evidence that the responses to distinct erythrocytic stage antigens could be differentially regulated. The present study was designed to compare the antibody response to three asexual erythrocytic stage antigens vaccine candidates of P. vivax. Recombinant proteins representing the 19 kDa C-terminal region of MSP-1(PvMSP19), apical membrane antigen n-1 ectodomain (PvAMA-1), and the region II of duffy binding protein (PvDBP-RII) were compared in their ability to bind to IgG antibodies of serum samples collected from 220 individuals from the state of Pará, in the North of Brazil. During patent infection with P. vivax, the frequency of individuals with IgG antibodies to PvMSP1(19), PvAMA-1, and PvDBP-RII were 95, 72.7, and 44.5% respectively. Although the frequency of responders to PvDBP-RII was lower, this frequency increased in individuals following multiple malarial infections. Individually, the specific antibody levels did not decline significantly nine months after treatment, except to PvMSP1(19). Our results further confirm a complex regulation of the immune response to distinct blood stage antigens. The reason for that is presently unknown but it may contribute to the high risk of re-infection in individuals living in the endemic areas.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D010966 Plasmodium vivax A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions. Plasmodium vivaxs,vivax, Plasmodium
D011994 Recombinant Proteins Proteins prepared by recombinant DNA technology. Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000913 Antibodies, Protozoan Immunoglobulins produced in a response to PROTOZOAN ANTIGENS. Protozoan Antibodies
D016780 Malaria, Vivax Malaria caused by PLASMODIUM VIVAX. This form of malaria is less severe than MALARIA, FALCIPARUM, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day. Plasmodium vivax Malaria,Malaria, Plasmodium vivax,Vivax Malaria
D017780 Malaria Vaccines Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents. Malaria Vaccine,Malarial Vaccine,Malarial Vaccines,Vaccine, Malaria,Vaccine, Malarial,Vaccines, Malaria,Vaccines, Malarial
D020066 Merozoite Surface Protein 1 A surface protein found on Plasmodium species which induces a T-cell response. The antigen is polymorphic, sharing amino acid sequence homology among PLASMODIUM FALCIPARUM; PLASMODIUM CHABAUDI; PLASMODIUM VIVAX; and PLASMODIUM YOELII. MSP1,MSA-1,MSA-1 Protein,MSA1,MSA1 Protein,MSP-1,MSP1, P. vivax,Major Merozoite Surface Protein Precursor,Merozoite Surface Antigen 1,Merozoite Surface Protein-1,PFM-PSCP,PMMSA,Plasmodium falciparum Merozoite Precursor Surface Coat Protein,MSA 1 Protein,P. vivax MSP1,Protein, MSA-1,Protein, MSA1,Surface Protein-1, Merozoite

Related Publications

Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
October 1992, The American journal of tropical medicine and hygiene,
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
September 2023, PLoS neglected tropical diseases,
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
March 1948, British medical journal,
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
January 2024, Scientific reports,
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
December 2015, PLoS neglected tropical diseases,
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
June 1983, Lancet (London, England),
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
January 1992, Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases,
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
January 2024, Biomolecules,
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
August 2021, Parasites & vectors,
Mayara B Barbedo, and Ricardo Ricci, and Maria Carolina S Jimenez, and Maristela G Cunha, and Syed S Yazdani, and Chetan E Chitnis, and Mauricio M Rodrigues, and Irene S Soares
January 1994, Memorias do Instituto Oswaldo Cruz,
Copied contents to your clipboard!