Bactericidal effects of bioactive glasses on clinically important aerobic bacteria. 2008

Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
Department of Medical Microbiology, University of Turku, Kiinamyllynkatu 13, Turku 20500, Finland. laevmu@utu.fi

Bioactive glasses (BAGs) have been studied for decades for clinical use, and they have found many dental and orthopedic applications. BAGs have also been shown to have an antibacterial effect e.g., on some oral microorganisms. In this extensive work we show that six powdered BAGs and two sol-gel derived materials have a clear antibacterial effect on 29 clinically important bacterial species. We also incorporated a rapid and accurate flow cytometric (FCM) method to calculate and standardize the numbers of viable bacteria inoculated in the suspensions used in the tests for antibacterial activity. In all materials tested growth inhibition could be demonstrated, although the concentration and time needed for the effect varied depending on the BAG. The most effective glass was S53P4, which had a clear growth-inhibitory effect on all pathogens tested. The sol-gel derived materials CaPSiO and CaPSiO II also showed a strong antibacterial effect. In summary, BAGs were found to clearly inhibit the growth of a wide selection of bacterial species causing e.g., infections on the surfaces of prostheses in the body after implantation.

UI MeSH Term Description Entries
D008422 Materials Testing The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility. Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D011208 Powders Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed) Powder
D002516 Ceramics Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed) Ceramic
D004867 Equipment Design Methods and patterns of fabricating machines and related hardware. Design, Equipment,Device Design,Medical Device Design,Design, Medical Device,Designs, Medical Device,Device Design, Medical,Device Designs, Medical,Medical Device Designs,Design, Device,Designs, Device,Designs, Equipment,Device Designs,Equipment Designs
D005434 Flow Cytometry Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake. Cytofluorometry, Flow,Cytometry, Flow,Flow Microfluorimetry,Fluorescence-Activated Cell Sorting,Microfluorometry, Flow,Cell Sorting, Fluorescence-Activated,Cell Sortings, Fluorescence-Activated,Cytofluorometries, Flow,Cytometries, Flow,Flow Cytofluorometries,Flow Cytofluorometry,Flow Cytometries,Flow Microfluorometries,Flow Microfluorometry,Fluorescence Activated Cell Sorting,Fluorescence-Activated Cell Sortings,Microfluorimetry, Flow,Microfluorometries, Flow,Sorting, Fluorescence-Activated Cell,Sortings, Fluorescence-Activated Cell
D005456 Fluorescent Dyes Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. Flourescent Agent,Fluorescent Dye,Fluorescent Probe,Fluorescent Probes,Fluorochrome,Fluorochromes,Fluorogenic Substrates,Fluorescence Agents,Fluorescent Agents,Fluorogenic Substrate,Agents, Fluorescence,Agents, Fluorescent,Dyes, Fluorescent,Probes, Fluorescent,Substrates, Fluorogenic
D005898 Glass Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
D000890 Anti-Infective Agents Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. Anti-Infective Agent,Anti-Microbial Agent,Antimicrobial Agent,Microbicide,Microbicides,Anti-Microbial Agents,Antiinfective Agents,Antimicrobial Agents,Agent, Anti-Infective,Agent, Anti-Microbial,Agent, Antimicrobial,Agents, Anti-Infective,Agents, Anti-Microbial,Agents, Antiinfective,Agents, Antimicrobial,Anti Infective Agent,Anti Infective Agents,Anti Microbial Agent,Anti Microbial Agents
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial

Related Publications

Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
February 2008, Journal of materials science. Materials in medicine,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
January 2013, Journal of the Royal Society, Interface,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
April 2015, American journal of dentistry,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
July 2010, Journal of biomedical materials research. Part A,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
December 2017, International journal of antimicrobial agents,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
December 2019, Journal of clinical microbiology,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
March 1973, Die Medizinische Welt,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
April 1973, Applied microbiology,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
January 2013, PloS one,
Eveliina Munukka, and Outi Leppäranta, and Mika Korkeamäki, and Minna Vaahtio, and Timo Peltola, and Di Zhang, and Leena Hupa, and Heimo Ylänen, and Jukka I Salonen, and Matti K Viljanen, and Erkki Eerola
August 2017, Journal of dental research,
Copied contents to your clipboard!