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Lymphocyte and neutrophil dysfunction associated with hepatitis B virus and hepatitis non-A, non-B virus infection in the chimpanzee. 1991
L J Lafrado, and
M A Javadian, and
J M Marr, and
K A Wright, and
J C Kelliher, and
C S Dezzutti, and
L Cummins, and
R G Olsen
Ohio State University, Center for Retrovirus Research, Columbus.
Chimpanzees were examined for the effect of viral hepatitis infections on specific and nonspecific immune response mechanisms. The data suggest that infection with either hepatitis B virus or hepatitis non-A, non-B virus may result in suppression of cellular immune response components. Mitogen-induced lymphocyte proliferation was lower in virus-infected chimpanzees than in naive animals. Neutrophils from virus infected animals exhibited decreased or altered chemiluminescence kinetics.
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