Biomaterial Database

Efficacy of triclabendazole against natural infections of Fascioloides magna in wapiti. 1991

M J Pybus, and D K Onderka, and N Cool

Alberta Fish and Wildlife Division, Edmonton, Canada.

Fourteen free-ranging adult wapiti (Cervus elaphus nelsoni) were captured in Banff National Park, Alberta (Canada) and held in captivity near Edmonton. A 24% suspension of triclabendazole at doses of 30 to 100 mg/kg body weight was drenched into the rumen of eight females and four males. Two male wapiti were used as untreated controls. Animals were killed and examined at 4 (n = 3), 6 (n = 4), or 8 (n = 4) wk after treatment. Efficacy was 90% against immature Fascioloides magna collected 4 wk after treatment and 98% against adult flukes collected 4, 6 or 8 wk after treatment. All 32 flukes recovered from control wapiti were active and apparently healthy. Treatment at 50 to 60 mg/kg is recommended against F. magna in wapiti. A protocol for treating infected wapiti is outlined.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D003670	Deer	The family Cervidae of 17 genera and 45 species occurring nearly throughout North America, South America, and Eurasia, on most associated continental islands, and in northern Africa. Wild populations of deer have been established through introduction by people in Cuba, New Guinea, Australia, New Zealand, and other places where the family does not naturally occur. They are slim, long-legged and best characterized by the presence of antlers. Their habitat is forests, swamps, brush country, deserts, and arctic tundra. They are usually good swimmers; some migrate seasonally. (Walker's Mammals of the World, 5th ed, p1362)	Deers
D005212	Fasciolidae	A family of flukes of the class Trematoda occurring primarily in the liver of animals and man. There are six genera: Fasciola, Fasciolopsis, Fascioloides, Tenuifasciola, Parafasciolopsis, and Protofasciola. The adult form of Fasciolopsis occurs in the intestines of pigs and man.	Fascioloides,Fasciolopsis,Fascioloide,Fasciolopses
D005213	Fascioloidiasis	Infection of cattle and other herbivores with the giant liver fluke Fascioloides magna. It is characterized by extensive destruction of the liver parenchyma.	Fascioloidiases
D005260	Female		Females
D000077682	Triclabendazole	Benzimidazole antiplatyhelmintic agent that is used for the treatment of FASCIOLIASIS and PARAGONIMIASIS.	Egaten,6-chloro-5-(2,3-dichlorophenoxy)-2-methylthiobenzimidazole,Fasicare,Fasinex,Flukare,Tremacide
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000871	Anthelmintics	Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.	Anthelmintic,Antihelmintic,Vermifuge,Vermifuges,Antihelmintics
D001562	Benzimidazoles	Compounds with a BENZENE fused to IMIDAZOLES.