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Oral vaccination of skunks with raccoon poxvirus recombinants expressing the rabies glycoprotein or the nucleoprotein. 1991
M Fekadu, and
J H Shaddock, and
J W Sumner, and
D W Sanderlin, and
J C Knight, and
J J Esposito, and
G M Baer
Viral and Rickettsial Zoonoses Branch, Centers for Disease Control, Atlanta, Georgia 30333.
Twenty nine skunks (Mephitis mephitis) were vaccinated orally with raccoon poxvirus (RCN) recombinants: 10 with a recombinant expressing the rabies virus glycoprotein (RCNRG), 10 with RCNRG mixed with a recombinant expressing the rabies virus nucleoprotein (RCNRN) and nine with RCN alone. Rabies virus neutralizing antibodies were detected in six of the 20 skunks; five skunks (three given RCNRG, two given a mixture of recombinants) survived a rabies challenge that was lethal for nine skunks vaccinated with RCN alone.
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