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Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. 2007
Robert M Waterhouse, and
Evgenia V Kriventseva, and
Stephan Meister, and
Zhiyong Xi, and
Kanwal S Alvarez, and
Lyric C Bartholomay, and
Carolina Barillas-Mury, and
Guowu Bian, and
Stephanie Blandin, and
Bruce M Christensen, and
Yuemei Dong, and
Haobo Jiang, and
Michael R Kanost, and
Anastasios C Koutsos, and
Elena A Levashina, and
Jianyong Li, and
Petros Ligoxygakis, and
Robert M Maccallum, and
George F Mayhew, and
Antonio Mendes, and
Kristin Michel, and
Mike A Osta, and
Susan Paskewitz, and
Sang Woon Shin, and
Dina Vlachou, and
Lihui Wang, and
Weiqi Wei, and
Liangbiao Zheng, and
Zhen Zou, and
David W Severson, and
Alexander S Raikhel, and
Fotis C Kafatos, and
George Dimopoulos, and
Evgeny M Zdobnov, and
George K Christophides
Division of Cell and Molecular Biology, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.
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