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The effect of adjuvant chemotherapy on the circulating levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) has been investigated in postmenopausal breast cancer patients. In the patients who received adjuvant CMF-chemotherapy, there was a significant decrease in the circulating FSH, LH and PRL levels compared to healthy age-matched controls. A positive correlation was found between this decline in the FSH, LH and PRL values and the regression of tumor size following chemotherapy regimen.
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