| D008099 |
Liver |
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. |
Livers |
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| D010713 |
Phosphatidylcholines |
Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety. |
Choline Phosphoglycerides,Choline Glycerophospholipids,Phosphatidyl Choline,Phosphatidyl Cholines,Phosphatidylcholine,Choline, Phosphatidyl,Cholines, Phosphatidyl,Glycerophospholipids, Choline,Phosphoglycerides, Choline |
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| D002796 |
Choline Deficiency |
A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984) |
Deficiency, Choline,Choline Deficiencies,Deficiencies, Choline |
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| D000097202 |
ATP-Binding Cassette Sub-Family B Member 4 |
An ATP-binding cassette, sub-family B protein that functions in translocating PHOSPHATIDYLCHOLINES from the inner to the outer leaflet of the canalicular membrane of the HEPATOCYTES. |
MDR2 Protein,Multidrug Resistance Protein 2,P-Glycoprotein 2,Pgp2 protein,Phosphatidylcholine Translocator ABCB4,2, P-Glycoprotein,ABCB4, Phosphatidylcholine Translocator,ATP Binding Cassette Sub Family B Member 4,P Glycoprotein 2,Translocator ABCB4, Phosphatidylcholine,protein, Pgp2 |
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| D000818 |
Animals |
Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. |
Animal,Metazoa,Animalia |
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| D001646 |
Bile |
An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum. |
Biliary Sludge,Sludge, Biliary |
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| D050918 |
Phosphatidylethanolamine N-Methyltransferase |
An enzyme that catalyses three sequential METHYLATION reactions for conversion of phosphatidylethanolamine to PHOSPHATIDYLCHOLINE. |
Cephalin N-Methyltransferase,PHET Methyltransferase II,Phosphatidylethanolamine Methyltransferase,Phosphatidylethanolamine N-Methyltransferase-2,Phosphatidylethanolamine-Methyltransferase II,Phosphatidylethanolamine-Phosphatidylcholine N-Methyltransferase,Phospholipid Methyltransferase II,S-Adenosylmethionine Phosphatidylethanolamine N-Methyltransferase,Cephalin N Methyltransferase,Methyltransferase II, PHET,Methyltransferase II, Phospholipid,Methyltransferase, Phosphatidylethanolamine,N-Methyltransferase, Cephalin,N-Methyltransferase, Phosphatidylethanolamine,N-Methyltransferase, Phosphatidylethanolamine-Phosphatidylcholine,N-Methyltransferase, S-Adenosylmethionine Phosphatidylethanolamine,N-Methyltransferase-2, Phosphatidylethanolamine,Phosphatidylethanolamine Methyltransferase II,Phosphatidylethanolamine N Methyltransferase,Phosphatidylethanolamine N Methyltransferase 2,Phosphatidylethanolamine N-Methyltransferase, S-Adenosylmethionine,Phosphatidylethanolamine Phosphatidylcholine N Methyltransferase,S Adenosylmethionine Phosphatidylethanolamine N Methyltransferase |
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| D051379 |
Mice |
The common name for the genus Mus. |
Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus |
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| D053858 |
Metabolic Networks and Pathways |
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites. |
Metabolic Networks,Metabolic Pathways,Metabolic Network,Metabolic Pathway,Network, Metabolic,Networks, Metabolic,Pathway, Metabolic,Pathways, Metabolic |
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| D018435 |
ATP Binding Cassette Transporter, Subfamily B |
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. |
Multidrug Resistance Proteins,P-Glycoproteins,ATP Binding Cassette Transporter, Sub-Family B,ATP-Binding Cassette, Sub-Family B Proteins,ATP Binding Cassette Transporter, Sub Family B,ATP Binding Cassette, Sub Family B Proteins,P Glycoproteins |
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