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The concentrations of estradiol and progesterone receptors are measured in the cytoplasmic and nuclear fractions of endometrial samples obtained by biopsy throughout the menstrual cycle. The standardized micromethod accounts for the sites occupied by endogenous hormones and for interference by androgen receptors and plasma binding proteins. In normal women, the cellular concentration of estradiol receptor increases early in the cycle and decreases steadily after ovulation. The progesterone receptor is maximum between the 10th and 15th day of the cycle and decreases during the luteal phase. The nuclear/cytoplasmic ratios of both receptors follow the variations of circulating hormones. These data constitute a new basis for physiopathological and pharmacological investigations on the hormonal control of the human uterus.
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
December 1988,
Laboratory investigation; a journal of technical methods and pathology,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
January 1979,
Obstetrics and gynecology annual,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
January 1975,
Journal of steroid biochemistry,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
August 1974,
Journal of steroid biochemistry,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
May 1984,
Sheng zhi yu bi yun = Reproduction and contraception,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
April 1980,
Steroids,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
January 1994,
Gynecologic and obstetric investigation,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
February 1974,
Endocrinology,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
March 1980,
American journal of obstetrics and gynecology,
F Bayard, and
S Damilano, and
P Robel, and
E E Baulieu
August 1979,
European journal of obstetrics, gynecology, and reproductive biology,
