Degenerative changes of the spine may involve the disc space, the facet joints, or the supportive and surrounding soft tissues. MR imaging is ideally suited for delineating the presence, extent, and complications of degenerative spinal disease. Other imaging modalities such as radiography, myelography, and CT may provide complimentary information in selected cases. Percutaneous procedures may be used to confirm that a morphologic abnormality is the source of symptoms. Correlation with clinical and electrophysiologic data is also helpful for accurate diagnosis. Combining the information obtained from imaging studies with the patient's clinical presentation is mandatory for determining the appropriate patient management strategy, especially true in patients afflicted with any condition directly attributed to the degenerative processes of the spine.