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Elucidating the spectrum of alpha-thalassemia mutations in Iran. 2007
Valeh Hadavi, and
Amir Hossein Taromchi, and
Mahdi Malekpour, and
Behjat Gholami, and
Hai-Yang Law, and
Navid Almadani, and
Fariba Afroozan, and
Farhad Sahebjam, and
Parisa Pajouh, and
Roxana Kariminejad, and
Mohammad Hassan Kariminejad, and
Azita Azarkeivan, and
Maryam Jafroodi, and
Ahmad Tamaddoni, and
Helene Puehringer, and
Christian Oberkanins, and
Hossein Najmabadi
Kariminejad-Najmabadi Pathology & Genetics Center, 14665/154, Tehran, Iran.
Alpha thalassemia (alpha-thal) is one of the most common hemoglobin (Hb) disorders in the world. Alpha-globin genes are located on chromosome 16. The majority of alpha-thal mutations are deletions but point mutations are found as well. Since the Iranian population is a mixture of different ethnic groups, frequency and distribution of alpha-globin mutations in various regions of the country need to be clarified. These findings can contribute to a wider understanding of this disorder.
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