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In seven healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the papilla of Vater. Synthetic secretin was intravenously infused in doses doubled every 20 min. The volume of pancreatic juice was proportional to the log of the secretin dose. A significant rise (P less than 0.05) in pancreatic juice flow was elicited at a dose as low as 8.05 ng per kg per hr. Maximum flow rate approximating 250 mul per 5 min per kg of body weight was attained during infusion of 129 ng per kg per hr. At the same dose maximal bicarbonate outputs averaging 383 muEq per hr per kg of body weight were obtained, whereas bicarbonate ion concentration approached peak values (135 +/- 9 muEq per ml) at 32.2 ng per kg per hr. Bicarbonate concentrations showed a tendency to fall at supramaximal doses. The effect of increasing secretin doses on bicarbonate and cyclic AMP concentrations was remarkably similar (rs = 0.635, P less than 0.001) suggesting the participation of cyclic AMP in human pancreatic bicarbonate secretion.
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
January 1981,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
February 1976,
The British journal of surgery,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
May 1980,
Zeitschrift fur Gastroenterologie,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
January 1978,
Surgical forum,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
January 1965,
Acta physiologica Scandinavica,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
August 1981,
Hepato-gastroenterology,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
August 1980,
The American journal of gastroenterology,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
March 1965,
Gastroenterology,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
September 1979,
Bollettino della Societa italiana di biologia sperimentale,
S Domschke, and
W Domschke, and
W Rösch, and
S J Konturek, and
E Wünsch, and
L Demling
January 1984,
Zeitschrift fur medizinische Laboratoriumsdiagnostik,
