BIOMAT Database Logo BIOMAT Database Logo

[Immunoregulation of vasoactive intestinal peptide on rat Leydig cells]. 2007

Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
School of Medicine, Shanghai Jiaotong University, Shanghai Institute of Immunology, Shanghai 200025, China.

OBJECTIVE To study the regulation of immune function of rat Leydig cells by vasoactive intestinal peptide (VIP). METHODS Rat Leydig cells were seperated and infected by UU, with or without the incubation with VIP. The expression of FasL on Leydig cells in different group was analysed by flow cytometry(FCM). The mRNA expression of IL-1, IL-6, TGF-beta and FasL of Leydig cells in different group was identified by RT-PCR. SD rats were infected by UU with or without the injection of VIP, and the testis tissnes of each group were har vested and observed under transmission electron microscope. RESULTS When testis was infected by UU, VIP up-regulated the mRNA expression of IL-1, IL-6, and TGF-beta, and down-regulated the expression of FasL in vitro. In addition, there was significant difference in testis morphous of rats from different group. CONCLUSIONS VIP could regulate the expression pattern of IL-1, IL-6, TGF-beta and FasL by Leydig cells, which may contribute to maintain immune privilege of the testis. VIP could regulate rat Leydig cell immune function.

UI MeSH Term Description Entries
D007375 Interleukin-1 A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation. IL-1,Lymphocyte-Activating Factor,Epidermal Cell Derived Thymocyte-Activating Factor,Interleukin I,Macrophage Cell Factor,T Helper Factor,Epidermal Cell Derived Thymocyte Activating Factor,Interleukin 1,Lymphocyte Activating Factor
D007985 Leydig Cells Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced. Interstitial Cells, Testicular,Leydig Cell,Testicular Interstitial Cell,Testicular Interstitial Cells,Cell, Leydig,Cell, Testicular Interstitial,Cells, Leydig,Cells, Testicular Interstitial,Interstitial Cell, Testicular
D008297 Male Males
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005765 Gastrointestinal Agents Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. Digestants,Gastric Agents,Gastric Drugs,Gastrointestinal Drugs,Agents, Gastric,Agents, Gastrointestinal,Drugs, Gastric,Drugs, Gastrointestinal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013737 Testis The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS. Testicles,Testes,Testicle
D014660 Vasoactive Intestinal Peptide A highly basic, 28 amino acid neuropeptide released from intestinal mucosa. It has a wide range of biological actions affecting the cardiovascular, gastrointestinal, and respiratory systems and is neuroprotective. It binds special receptors (RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE). VIP (Vasoactive Intestinal Peptide),Vasoactive Intestinal Polypeptide,Vasointestinal Peptide,Intestinal Peptide, Vasoactive,Intestinal Polypeptide, Vasoactive,Peptide, Vasoactive Intestinal,Peptide, Vasointestinal,Polypeptide, Vasoactive Intestinal
D015850 Interleukin-6 A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS. Hepatocyte-Stimulating Factor,Hybridoma Growth Factor,IL-6,MGI-2,Myeloid Differentiation-Inducing Protein,Plasmacytoma Growth Factor,B Cell Stimulatory Factor-2,B-Cell Differentiation Factor,B-Cell Differentiation Factor-2,B-Cell Stimulatory Factor 2,B-Cell Stimulatory Factor-2,BSF-2,Differentiation Factor, B-Cell,Differentiation Factor-2, B-Cell,IFN-beta 2,IL6,Interferon beta-2,B Cell Differentiation Factor,B Cell Differentiation Factor 2,B Cell Stimulatory Factor 2,Differentiation Factor 2, B Cell,Differentiation Factor, B Cell,Differentiation-Inducing Protein, Myeloid,Growth Factor, Hybridoma,Growth Factor, Plasmacytoma,Hepatocyte Stimulating Factor,Interferon beta 2,Interleukin 6,Myeloid Differentiation Inducing Protein,beta-2, Interferon
D016212 Transforming Growth Factor beta A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. Bone-Derived Transforming Growth Factor,Platelet Transforming Growth Factor,TGF-beta,Milk Growth Factor,TGFbeta,Bone Derived Transforming Growth Factor,Factor, Milk Growth,Growth Factor, Milk

Related Publications

Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Vasoactive intestinal peptide receptors on AR42J rat pancreatic acinar cells.
August 1991, Biochemical and biophysical research communications,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Identification of specific binding sites for vasoactive intestinal peptide in rat testis Leydig cells and study of developmental changes.
November 1989, Biochemistry international,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Interaction of vasoactive intestinal peptide (VIP) with rat lymphoid cells.
January 1986, Peptides,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Interaction of vasoactive intestinal peptide with rat small intestinal epithelial cells after intestinal resection.
July 1985, Bioscience reports,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Receptors for vasoactive intestinal peptide on isolated epithelial cells of rat ventral prostate.
December 1983, Biochimica et biophysica acta,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Ontogenic development of vasoactive intestinal peptide receptors in rat intestinal cells and liver.
December 1987, Endocrinology,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
[The effect of vasoactive intestinal peptide on the rat ovary].
August 1990, Nihon Naibunpi Gakkai zasshi,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Effect of vasoactive intestinal peptide on isolated perfused rat kidney.
November 1985, The American journal of physiology,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Characterization of vasoactive intestinal peptide receptors on rat alveolar macrophages.
September 1994, The American journal of physiology,
Wei Wang, and Ye-bin Xi, and Guang-jie Chen, and Jing Hao, and Tian-wei Shen, and Bao-guo Wang, and Wei-yi Li
Uptake of vasoactive intestinal peptide by rat liver.
August 1982, The American journal of physiology,
Copied contents to your clipboard!