Biomaterial Database

Adsorptive stripping voltammetric behavior and determination of anticholinergic agent oxybutynin chloride on a mercury electrode. 2007

Rajeev Jain, and Keisham Radhapyari, and Nimisha Jadon

School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India. rajeevjain54@yahoo.co.in

Oxybutynin chloride is an antispasmodic, anticholinergic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. Its electrochemical behavior in phosphate buffers of pH range 2-10 at a hanging mercury drop electrode has been investigated using cyclic voltammetry, differential pulse cathodic adsorptive stripping voltammetry (DPCAdSV), and squarewave cathodic adsorptive stripping voltammetry (SWCAdSV). Voltammograms of the drug in phosphate buffer of pH 2-10 exhibited a single two-electron wave and it may be attributed to the reduction of the C[triple bond]C center. Based on the high adsorptive character of oxybutynin chloride onto the mercury electrode, a validated direct squarewave cathodic adsorptive stripping voltammetric and differential pulse cathodic adsorptive stripping voltammetric procedure has been developed for the determination of drug in bulk form and pharmaceutical formulation. The proposed SWCAdS and DPCAdS voltammetric methods allow quantitation over the range 1-18 and 1-17.6 microg mL(-1) with detection limits of 0.1 and 0.23 microg mL(-1), respectively. Precision and accuracy were also checked and were within the limits.

UI	MeSH Term	Description	Entries
D008333	Mandelic Acids	Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid).	Acids, Mandelic
D008956	Models, Chemical	Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.	Chemical Models,Chemical Model,Model, Chemical
D012044	Regression Analysis	Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.	Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D002626	Chemistry, Pharmaceutical	Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.	Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D004563	Electrochemistry	The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.	Electrochemistries
D004566	Electrodes	Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.	Anode,Anode Materials,Cathode,Cathode Materials,Anode Material,Anodes,Cathode Material,Cathodes,Electrode,Material, Anode,Material, Cathode
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863	Hydrogen-Ion Concentration	The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH	pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000327	Adsorption	The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.	Adsorptions
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor