Oral etoricoxib for pain relief during fractional curettage: a randomized controlled trial. 2007

Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
Department of Obstetrics and Gynaecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Rama IV Rd, Rachatavee, Bangkok 10400, Thailand. taew-p@hotmail.com

OBJECTIVE To compare the efficacy of oral etoricoxib and placebo combined with paracervical block for pain relief during fractional curettage METHODS A double-blind, randomized controlled trial that included 220 women who underwent fractional curettage and received paracervical block for pain relief was done at Ramathibodi Hospital between September 2005 and June 2006. One hundred and ten women were randomly allocated to the etoricoxib group (90 mg, tablet) and 110 to the placebo group. The main outcome was the patient's assessment of intensity of pain measured by verbal rating scales after speculum insertion, during fractional curettage, immediately after curettage, and 30 minutes after curettage. RESULTS Demographic data including age, previous vaginal deliveries, and history of curettage were not significantly different between etoricoxib group and placebo group. Most common indication for fractional curettage was menometrorrhagia in both groups. Pain score in etoricoxib group was significant lower during fractional curettage (5 vs. 6, p = 0.04), immediately after curettage (2 vs. 3, p = 0. 009), and 30 minutes after curettage (0 vs. 1, p = 0.003). Comparing the number of patients with mild pain (score 0-3), there were significant higher number of mild pain patient at the time during curettage (39 vs. 20 cases), immediate after curettage (78 vs. 60 cases), and 30 minutes after curettage (107 vs. 100 cases) in etoricoxib group. CONCLUSIONS Combination of etoricoxib with paracervical block for reduction of pain during fractional curettage had statistically significant lower pain scale when compared with placebo with paracervical block. However the difference was small and may have questionable clinical significance.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010147 Pain Measurement Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies. Analgesia Tests,Analogue Pain Scale,Formalin Test,McGill Pain Questionnaire,Nociception Tests,Pain Assessment,Pain Intensity,Pain Severity,Tourniquet Pain Test,Visual Analogue Pain Scale,Analog Pain Scale,Assessment, Pain,McGill Pain Scale,Visual Analog Pain Scale,Analgesia Test,Analog Pain Scales,Analogue Pain Scales,Formalin Tests,Intensity, Pain,Measurement, Pain,Nociception Test,Pain Assessments,Pain Intensities,Pain Measurements,Pain Questionnaire, McGill,Pain Scale, Analog,Pain Scale, Analogue,Pain Scale, McGill,Pain Severities,Pain Test, Tourniquet,Questionnaire, McGill Pain,Scale, Analog Pain,Scale, Analogue Pain,Scale, McGill Pain,Severity, Pain,Test, Analgesia,Test, Formalin,Test, Nociception,Test, Tourniquet Pain,Tests, Nociception,Tourniquet Pain Tests
D010149 Pain, Postoperative Pain during the period after surgery. Acute Post-operative Pain,Acute Postoperative Pain,Chronic Post-operative Pain,Chronic Post-surgical Pain,Chronic Postoperative Pain,Chronic Postsurgical Pain,Pain, Post-operative,Persistent Postsurgical Pain,Post-operative Pain,Post-operative Pain, Acute,Post-operative Pain, Chronic,Post-surgical Pain,Postoperative Pain, Acute,Postoperative Pain, Chronic,Postsurgical Pain,Postoperative Pain,Acute Post operative Pain,Chronic Post operative Pain,Chronic Post surgical Pain,Chronic Postsurgical Pains,Pain, Acute Post-operative,Pain, Acute Postoperative,Pain, Chronic Post-operative,Pain, Chronic Post-surgical,Pain, Chronic Postoperative,Pain, Chronic Postsurgical,Pain, Persistent Postsurgical,Pain, Post operative,Pain, Post-surgical,Pain, Postsurgical,Post operative Pain,Post operative Pain, Acute,Post operative Pain, Chronic,Post surgical Pain,Post-operative Pains,Post-surgical Pain, Chronic,Postsurgical Pain, Chronic,Postsurgical Pain, Persistent
D010919 Placebos Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol. Sham Treatment
D011725 Pyridines Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.
D004107 Dilatation and Curettage Dilatation of the cervix uteri followed by a scraping of the endometrium with a curette. Curettage and Dilatation,Dilatation & Curettage
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077613 Etoricoxib A sulfone and pyridine derivative that acts as a cyclooxygenase-2 inhibitor. It is used as a NSAID for the treatment of pain associated with RHEUMATOID ARTHRITIS and ANKYLOSING SPONDYLITIS. It is also used for the short-term treatment of moderate postoperative dental pain. Arcoxia,L-791456,MK 0663,MK-0663,L 791456,L791456,MK0663

Related Publications

Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
September 2008, European journal of obstetrics, gynecology, and reproductive biology,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
October 2001, Obstetrics and gynecology,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
January 2008, Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
October 2015, The Indian journal of medical research,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
July 2010, American journal of obstetrics and gynecology,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
September 2005, Obstetrics and gynecology,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
September 2018, Journal of pediatric orthopedics,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
December 2017, Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
July 2015, Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
Wilaiporn Phittayawechwiwat, and Chalermsri Thanantaseth, and Nathpong Israngura Na Ayudhya, and Pratak O-Prasertsawat, and Jitlada Kongprasert
March 2009, Birth (Berkeley, Calif.),
Copied contents to your clipboard!