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Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors. 2008
Aldo Andreani, and
Silvia Burnelli, and
Massimiliano Granaiola, and
Massimo Guardigli, and
Alberto Leoni, and
Alessandra Locatelli, and
Rita Morigi, and
Mirella Rambaldi, and
Manuela Rizzoli, and
Lucilla Varoli, and
Aldo Roda
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Via Belmeloro 6, 40126 Bologna, Italy. aldo.andreani@unibo.it
The synthesis of a new series of imidazo[2,1-b]thiazole derivatives is described. They were tested as potential acetylcholinesterase and butyrylcholinesterase inhibitors by means of a chemiluminescent microassay. Although most of the new compounds did not show significant cholinesterase inhibition potency, three of them displayed selective antiacetylcholinesterase activity in the micromolar range.
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