-transparent.png){kind=logo}
Intracerebroventricularly (i.vt.) administered lanthanum chloride was found to produce antinociceptive effects as measured by the mouse tail-flick and hot plate tests and the rat tail-flick test. These antinociceptive effects were reduced by peripheral administration of the narcotic antagonist naloxone or by i.vt. administration of calcium chloride. In addition, animals made tolerant to morphine were also tolerant to the effects of La+++. In morphine-dependent mice, the incidence of both abrupt and naloxone-precipitated withdrawal jumping was reduced by La+++ administration. In view of the known inhibitory effects of La+++ on Ca++ binding and movement, these findings suggest that alterations in Ca++ localization may be involved in the analgetic action of narcotic drugs as well as the development of narcotic tolerance and dependence.
R A Harris, and
H H Loh, and
E L Way
November 1989,
Pharmacology, biochemistry, and behavior,
R A Harris, and
H H Loh, and
E L Way
January 1968,
Research publications - Association for Research in Nervous and Mental Disease,
R A Harris, and
H H Loh, and
E L Way
December 2010,
Pharmacology, biochemistry, and behavior,
R A Harris, and
H H Loh, and
E L Way
July 1973,
Research communications in chemical pathology and pharmacology,
R A Harris, and
H H Loh, and
E L Way
September 1982,
European journal of pharmacology,
R A Harris, and
H H Loh, and
E L Way
October 1972,
The Journal of pharmacology and experimental therapeutics,
R A Harris, and
H H Loh, and
E L Way
January 1995,
Life sciences,
R A Harris, and
H H Loh, and
E L Way
July 1979,
Life sciences,
R A Harris, and
H H Loh, and
E L Way
October 1993,
Pharmacology, biochemistry, and behavior,
R A Harris, and
H H Loh, and
E L Way
August 2001,
Pain,
