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Atrophy of cholinergic neurons is a prominent component of Alzheimer's disease, and may explain in part the profound memory loss that is characteristic of patients with this disorder. Previous studies in animal models have shown that infusions of nerve growth factor into the adult brain can prevent both age-related and lesion-induced cholinergic neuronal atrophy. Recently, recombinant human nerve growth factor was found biologically active in nonprimate animal models. In the present experiment, recombinant human nerve growth factor infusions into the brains of adult primates prevented lesion-induced cholinergic neuronal degeneration and promoted cholinergic neurite sprouting. These findings provide additional support for potential therapeutic trials of human nerve growth factor in patients with Alzheimer's disease.
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
November 1990,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
April 1996,
Gene therapy,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
August 1996,
Experimental neurology,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
March 1995,
Brain research,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
May 1991,
Experimental neurology,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
April 1996,
Neuroscience,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
December 1991,
Annals of neurology,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
January 2004,
Progress in brain research,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
February 2001,
Proceedings of the National Academy of Sciences of the United States of America,
M H Tuszynski, and
H Sang, and
K Yoshida, and
F H Gage
April 1989,
Trends in pharmacological sciences,
