OBJECTIVE To synthesize a new resin root canal filling material (NRCFM) and evaluate its stability in water and artificial saliva. METHODS The new root canal filling material was made of thermoplastic elastomer (TPE), ethylene vinyl acetate (EVA) and activity fillers. The NRCFM's stability in water and artificial saliva with different pH values was assessed using gravimetric analysis, ICP and FE-SEM. RESULTS NRCFM1 and NRCFM2 were successfully made. Gravimetric evaluation showed that the changes in mass over 30 days different solution medium for NRCFM1 and NRCFM2 were comparable to that of GP (P > 0.05) and significantly different from Resilon (P < 0.001). ICP showed slight changes in Si concentration for NRCFM1 and NRCFM2, Zn for GP, Na and Si for Resilon in the alkaline artificial saliva (pH 9.5). GP and Resilon showed release of Zn and Na respectively in distilled water whereas NRCFM1 and NRCFM2 were stable. FE-SEM micrographs showed that there were slight changes on the surface topography of NRCFM1 and NRCFM2. CONCLUSIONS The new resin root canal filling material NRCFM1 and NRCFM2 had good stability in different experimental solutions.