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The interaction between pancuronium, d-tubocurarine, polymyxin B, and neostigmine was studied in the rat diaphragm-phrenic nerve preparation. Polymyxin B (5 mug/ml) did not affect twitch tension alone but decreased the pancuronium ED50 from 0.8 mug/ml to 0.32 mug/ml and the d-tubocurarine ED50 from 0.25 mug/ml to 0.15 mug/ml. Neostigmine (0.2 to 10 mug/ml) antagonized pancuronium or d-tubocurarine-induced depression of twitch tension. In contrast, neostigmine (0.001 to 0.2 mug/ml) augmented polymyxin B depression. Similarly, neostigmine (0.1 mug/ml) augmented combined polymyxin B-pancuronium or polymyxin B-d-tubocurarine depression of twitch tension. The authors conclude that polymyxin B potentiates the neuromuscular blockade from pancuronium or d-tubocurarine and that neostigmine further augments this block.
L S Van Nyhuis, and
R D Miller, and
R P Fogdall
June 1986,
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L S Van Nyhuis, and
R D Miller, and
R P Fogdall
November 1972,
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L S Van Nyhuis, and
R D Miller, and
R P Fogdall
July 1982,
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L S Van Nyhuis, and
R D Miller, and
R P Fogdall
February 1993,
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L S Van Nyhuis, and
R D Miller, and
R P Fogdall
September 1981,
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L S Van Nyhuis, and
R D Miller, and
R P Fogdall
January 1967,
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L S Van Nyhuis, and
R D Miller, and
R P Fogdall
April 1987,
Anesthesiology,
L S Van Nyhuis, and
R D Miller, and
R P Fogdall
January 1974,
Anesthesia and analgesia,
L S Van Nyhuis, and
R D Miller, and
R P Fogdall
January 1971,
Revista brasileira de anestesiologia,
L S Van Nyhuis, and
R D Miller, and
R P Fogdall
July 1984,
Proceedings of the National Science Council, Republic of China. Part B, Life sciences,
