BIOMAT Database Logo BIOMAT Database Logo

GABAergic modulation of binge-like ethanol intake in C57BL/6J mice. 2007

Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Behavioral Neuroscience, Department of Psychology, Binghamton University -- SUNY, Binghamton, NY 13902-6000, United States.

GABA receptor systems have long been implicated in alcoholism, and GABAergic drugs have demonstrated efficacy in altering alcohol intake in some rodent models. The present study was designed to assess the effects of baclofen, muscimol, and gaboxadol (THIP) in a variation on a new mouse model of binge-like ethanol intake. Three hours into their dark cycle, male and female C57BL/6J mice were given access to a 20% unsweetened ethanol solution for 2 h each day, for four days. On day five, mice received varying doses of baclofen, muscimol or THIP and were allowed access to 20% ethanol for 60 min. Baclofen dose-dependently increased binge-like ethanol intake, while both muscimol and THIP reduced ethanol intake. Subsequent studies testing the effect of baclofen, muscimol and THIP on water intake using the same procedure revealed that whereas baclofen had no significant effect, muscimol and THIP both reduced the measure. These results add to the growing literature suggesting a role for GABA receptor systems in the modulation of ethanol intake. However, whereas the role of GABA(B) receptor systems seems selective in the modulation of binge-like ethanol intake, the role for GABA(A) receptor systems appears to also extend to general fluid intake.

UI MeSH Term Description Entries
D007555 Isoxazoles Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions. Isoxazole
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009118 Muscimol A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies. Agarin,Pantherine
D002492 Central Nervous System Depressants A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents). CNS Depressants,Depressants, CNS
D003624 Darkness The absence of light. Darknesses
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004856 Postural Balance A POSTURE in which an ideal body mass distribution is achieved. Postural balance provides the body carriage stability and conditions for normal functions in stationary position or in movement, such as sitting, standing, or walking. Postural Control,Posture Balance,Posture Control,Posture Equilibrium,Balance, Postural,Musculoskeletal Equilibrium,Postural Equilibrium,Balance, Posture,Control, Postural,Control, Posture,Equilibrium, Musculoskeletal,Equilibrium, Postural,Equilibrium, Posture,Postural Controls,Posture Balances,Posture Controls,Posture Equilibriums
D005260 Female Females
D005680 gamma-Aminobutyric Acid The most common inhibitory neurotransmitter in the central nervous system. 4-Aminobutyric Acid,GABA,4-Aminobutanoic Acid,Aminalon,Aminalone,Gammalon,Lithium GABA,gamma-Aminobutyric Acid, Calcium Salt (2:1),gamma-Aminobutyric Acid, Hydrochloride,gamma-Aminobutyric Acid, Monolithium Salt,gamma-Aminobutyric Acid, Monosodium Salt,gamma-Aminobutyric Acid, Zinc Salt (2:1),4 Aminobutanoic Acid,4 Aminobutyric Acid,Acid, Hydrochloride gamma-Aminobutyric,GABA, Lithium,Hydrochloride gamma-Aminobutyric Acid,gamma Aminobutyric Acid,gamma Aminobutyric Acid, Hydrochloride,gamma Aminobutyric Acid, Monolithium Salt,gamma Aminobutyric Acid, Monosodium Salt

Related Publications

Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice.
July 2016, Addiction biology,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Medial prefrontal cortex neuropeptide Y modulates binge-like ethanol consumption in C57BL/6J mice.
May 2019, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Different Molecular/Behavioral Endophenotypes in C57BL/6J Mice Predict the Impact of OX1 Receptor Blockade on Binge-Like Ethanol Intake.
January 2017, Frontiers in behavioral neuroscience,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Angiotensin II stimulates intake of ethanol in C57BL/6J mice.
September 1999, Physiology & behavior,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces binge-like ethanol intake in male C57BL/6J mice.
June 2009, Behavioral neuroscience,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Adenosinergic regulation of binge-like ethanol drinking and associated locomotor effects in male C57BL/6J mice.
August 2015, Pharmacology, biochemistry, and behavior,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Protective and therapeutic benefits of environmental enrichment on binge-like sucrose intake in C57BL/6J mice.
July 2019, Appetite,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Repeated cycles of binge-like ethanol (EtOH)-drinking in male C57BL/6J mice augments subsequent voluntary EtOH intake but not other dependence-like phenotypes.
October 2013, Alcoholism, clinical and experimental research,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Using drinking in the dark to model prenatal binge-like exposure to ethanol in C57BL/6J mice.
September 2008, Developmental psychobiology,
Eileen M Moore, and Kristen M Serio, and Karen J Goldfarb, and Sandra Stepanovska, and David N Linsenbardt, and Stephen L Boehm
Bupropion, Alone and in Combination with Naltrexone, Blunts Binge-Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL/6J Mice.
May 2019, Alcoholism, clinical and experimental research,
Copied contents to your clipboard!