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Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection. 2007
Marcio L Rodrigues, and
Li Shi, and
Eliana Barreto-Bergter, and
Leonardo Nimrichter, and
Sandra E Farias, and
Elaine G Rodrigues, and
Luiz R Travassos, and
Joshua D Nosanchuk
Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil. marcio@micro.ufrj.br
Glucosylceramides (GlcCer) are involved in the regulation of Cryptococcus neoformans virulence. In the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.
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