Three previous psychophysical studies have demonstrated that interaural time difference (ITD) coding mechanisms can undergo frequency-specific, selective adaptation. We sought to determine whether this phenomenon extends to the pitch domain, by employing the same psycho-physical paradigm as one used previously, but with harmonic tone complexes lacking energy at the fundamental frequency. Ten normal listeners participated in experiment 1. Psychometric functions for ITDs were obtained for harmonic tone complexes with fundamental frequencies of 110 Hz and 185 Hz, before and after selective adaptation with complexes of the same fundamental frequencies lateralised to opposite sides. In experiment 1, each subject was tested twice. On separate days, subjects were tested with 110 Hz and 185 Hz stimuli that were either partially resolvable complexes or unresolvable ones. Both partially resolved and unresolved stimuli supported adaptation, and at both fundamental frequencies. In experiment 2, which employed nine listeners, the adaptor tone complexes were presented in conjunction with a diotic noise background designed to mask difference tones generated by the adaptor stimuli. The use of the masker had little effect on the mean strength of the adaptation effected by the unresolved adaptor stimuli, and only slightly weakened the adaptation effect found with the partially resolved adaptor stimuli. Taken together, these data constitute the first demonstration of selective adaptation exerted on a central mechanism in the pitch domain.