Progression of diabetic macular edema: correlation with blood retinal barrier permeability, retinal thickness, and retinal vessel diameter. 2007

Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark. bisan@glo.regionh.dk

OBJECTIVE To study the progression of diabetic macular edema (DME) in relation to baseline retinal thickness, retinal vascular leakage, and retinal trunk vessel diameters. METHODS In this single-center study, 45 patients were enrolled with 62 eligible eyes defined as having DME of a grade less than clinically significant macular edema (CSME). From the start, the patients were included in a multicenter study exploring the effect of ruboxistaurin versus placebo for 3.4 years. Subsequently, the patients were followed up for a mean of 5.7 years by optical coherence tomography, fundus photography, and vitreous fluorometry. Baseline values in eyes that progressed to photocoagulation treatment were compared with values from eyes that did not reach this endpoint. RESULTS In the 22 eyes of 18 patients in which CSME was diagnosed and treated, mean retinal vascular leakage at baseline was 5.6 (95% CI 4.2-7.6) nm/s, whereas eyes that did not progress to photocoagulation had a significantly lower mean leakage at baseline of 3.4 (95% CI 2.7-4.3) nm/s. No significant difference was found for measures of baseline retinal thickness or summarized retinal trunk vessel diameters. Eyes that progressed to photocoagulation treatment (mean delay to treatment, 3.6 years) had significantly higher foveal thicknesses than did nonprogressing eyes, from 18 months after study initiation. CONCLUSIONS Progression to photocoagulation treatment for CSME was associated with higher retinal vascular leakage at baseline, whereas baseline retinal vessel diameters and retinal thickness were comparable in progressing and nonprogressing eyes. Baseline leakage was the strongest predictor of progression from non-CSME to photocoagulation for CSME.

UI MeSH Term Description Entries
D008269 Macular Edema Fluid accumulation in the outer layer of the MACULA LUTEA that results from intraocular or systemic insults. It may develop in a diffuse pattern where the macula appears thickened or it may acquire the characteristic petaloid appearance referred to as cystoid macular edema. Although macular edema may be associated with various underlying conditions, it is most commonly seen following intraocular surgery, venous occlusive disease, DIABETIC RETINOPATHY, and posterior segment inflammatory disease. (From Survey of Ophthalmology 2004; 49(5) 470-90) Central Retinal Edema, Cystoid,Cystoid Macular Edema,Macular Edema, Cystoid,Cystoid Macular Dystrophy,Cystoid Macular Edema, Postoperative,Irvine-Gass Syndrome,Macular Dystrophy, Dominant Cystoid,Edema, Cystoid Macular,Edema, Macular,Irvine Gass Syndrome,Syndrome, Irvine-Gass
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012160 Retina The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent. Ora Serrata
D001813 Blood-Retinal Barrier A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous. Retinal-Blood Barrier,Barrier, Blood-Retinal,Barrier, Retinal-Blood,Barriers, Blood-Retinal,Barriers, Retinal-Blood,Blood Retinal Barrier,Blood-Retinal Barriers,Retinal Blood Barrier,Retinal-Blood Barriers
D002199 Capillary Permeability The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement. Microvascular Permeability,Permeability, Capillary,Permeability, Microvascular,Vascular Permeability,Capillary Permeabilities,Microvascular Permeabilities,Permeabilities, Capillary,Permeabilities, Microvascular,Permeabilities, Vascular,Permeability, Vascular,Vascular Permeabilities
D003922 Diabetes Mellitus, Type 1 A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence. Diabetes Mellitus, Brittle,Diabetes Mellitus, Insulin-Dependent,Diabetes Mellitus, Juvenile-Onset,Diabetes Mellitus, Ketosis-Prone,Diabetes Mellitus, Sudden-Onset,Diabetes, Autoimmune,IDDM,Autoimmune Diabetes,Diabetes Mellitus, Insulin-Dependent, 1,Diabetes Mellitus, Type I,Insulin-Dependent Diabetes Mellitus 1,Juvenile-Onset Diabetes,Type 1 Diabetes,Type 1 Diabetes Mellitus,Brittle Diabetes Mellitus,Diabetes Mellitus, Insulin Dependent,Diabetes Mellitus, Juvenile Onset,Diabetes Mellitus, Ketosis Prone,Diabetes Mellitus, Sudden Onset,Diabetes, Juvenile-Onset,Diabetes, Type 1,Insulin Dependent Diabetes Mellitus 1,Insulin-Dependent Diabetes Mellitus,Juvenile Onset Diabetes,Juvenile-Onset Diabetes Mellitus,Ketosis-Prone Diabetes Mellitus,Sudden-Onset Diabetes Mellitus
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D003930 Diabetic Retinopathy Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION. Diabetic Retinopathies,Retinopathies, Diabetic,Retinopathy, Diabetic
D005260 Female Females

Related Publications

Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
October 2008, Retina (Philadelphia, Pa.),
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
November 2018, JAMA ophthalmology,
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
October 2005, Investigative ophthalmology & visual science,
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
December 2013, [Zhonghua yan ke za zhi] Chinese journal of ophthalmology,
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
January 2009, Arquivos brasileiros de oftalmologia,
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
November 2007, Ophthalmology,
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
September 2011, American journal of ophthalmology,
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
April 2021, World journal of diabetes,
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
August 1991, Archives of ophthalmology (Chicago, Ill. : 1960),
Birgit Sander, and Dorte Nellemann Thornit, and Lotte Colmorn, and Charlotte Strøm, and Aniz Girach, and Larry D Hubbard, and Henrik Lund-Andersen, and Michael Larsen
January 2016, Middle East African journal of ophthalmology,
Copied contents to your clipboard!