-transparent.png){kind=logo}
Recombinant interleukin-2 (rIL-2) is able to maintain the growth and multiplication of T-lymphocytes and IL-2 dependent CTLL-2 cells up to 28 days with the multiplication of T-lymphocytes as high as about 1000 fold. When rIL-2 and its monoclonal antibody were added together, the above functions of rIL-2 were specially blocked, showing that these biological functions were exerted specifically by rIL-2. The rIL-2 is also able to increase the natural killer (NK) activity up to 46-96%, while higher concentrations of rIL-2 might exhibit inhibitory effect. The cytotoxicity of lymphokine activated killer (LAK) cells induced by rIL-2 for killing HL-60 cell line and solid tumour (human lung carcinoma) reached 54.84% and 37.96%, respectively. All these results indicate that the biological functions of rIL-2 were quite similar to that of the natural one.
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
February 1985,
Journal of biological response modifiers,
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
January 1993,
Biotherapy (Dordrecht, Netherlands),
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
January 1988,
Developments in biological standardization,
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
March 1984,
Science (New York, N.Y.),
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
February 1991,
Clinical pharmacy,
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
January 1997,
Cancer immunology, immunotherapy : CII,
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
June 1986,
The Journal of clinical investigation,
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
April 1985,
Biochemical and biophysical research communications,
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
March 1998,
European cytokine network,
X Y Liu, and
J L Yu, and
H D Zheng, and
Y Chen, and
J F Shen, and
Z H Feng, and
Z C Chen, and
L F You, and
B H Sun, and
Y Y Zhou
November 1999,
Cytokine,
