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The 600 x g particulate fraction of gastric mucosal scrapings from rats was incubated with 3H-metiamide which saturated available binding sites at a concentration of 1 muM. Scatchard plots showed a single component with a Kd value of 0.2 muM. Unlabelled cimetidine and histamine competed with 3H-metiamide binding. The 600 x g particulate fraction also contained all of the hormone and sodium fluoride sensitive adenylyl cyclase. Adenylyl cyclase activity was not altered by histamine, pentagastrin or carbachol but was increased during incubation with prostaglandin E1, secretin and epinephrine. These findings do not support the hypthesis that gastric secretion is mediated by intracellular accumulation of cyclic AMP.
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
February 1973,
Nature,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
January 1977,
The American journal of digestive diseases,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
December 1971,
Annals of the New York Academy of Sciences,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
January 1974,
Surgical forum,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
June 1982,
The Australian and New Zealand journal of surgery,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
November 1974,
The American journal of digestive diseases,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
October 1977,
Gastroenterology,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
October 1983,
Life sciences,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
January 1979,
Indian journal of physiology and pharmacology,
G C Rosenfeld, and
E D Jacobson, and
W J Thompson
January 1980,
Gastroenterologia Japonica,
