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The direct effect of LH and FSH on cyclic AMP levels in specific cell types, isolated from the rat testes, was investigated in vitro. LH significantly stimulated cyclic AMP production in isolated interstitial cells and had only a slight effect on the isolated germ cells. FSH significantly stimulated cyclic AMP production in isolated seminiferous tubules, organ cultures of testes explants, and isolated Sertoli cells, with only a small response elicited in the germ cells. FSH had no effect on the cyclic AMP levels in interstitial cells and either freshly isolated or cultured peritubular cells. These data indicate that the Sertoli cells and interstitial cells are the main cell types in the testes which respond to FSH and LH respectively with increased cyclic AMP production. A possible slight effect of either hormone on the cyclic AMP level in the germ cells has not be ruled out.
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
August 1976,
Endocrinology,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
April 1974,
Endocrinology,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
September 1978,
Acta endocrinologica,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
July 1978,
Acta endocrinologica,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
January 1978,
Acta endocrinologica,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
August 1981,
FEBS letters,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
May 1990,
The Anatomical record,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
January 1975,
Journal of cyclic nucleotide research,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
January 1973,
Metabolism: clinical and experimental,
J J Heindel, and
R Rothenberg, and
G A Robison, and
A Steinberger
June 1971,
Archiv fur Gynakologie,
