| D007559 |
Ivermectin |
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form. |
Eqvalan,Ivomec,MK-933,Mectizan,Stromectol,MK 933,MK933 |
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| D008800 |
Mexico |
A country in NORTH AMERICA, bordering the Caribbean Sea and the Gulf of Mexico, between BELIZE and the UNITED STATES, and bordering the North Pacific Ocean, between Guatemala and the UNITED STATES. |
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| D001938 |
Brazil |
A country located on the eastern coast of South America, located between Colombia and Peru, that borders the Atlantic Ocean. It is bordered on the north by Venezuela, Guyana, Suriname, and French Guiana, on the south by Uruguay, and on the west by Argentina. The capital is Brasilia. |
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| D003105 |
Colombia |
A country in northern South America, bordering the Caribbean Sea, between Panama and Venezuela, and bordering the north Pacific Ocean, between Ecuador and Panama. The capital is Bogota. |
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| D004484 |
Ecuador |
A country in western South America, bordering the Pacific Ocean at the equator, between Colombia and Peru. |
Galapagos Islands |
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| D005369 |
Filaricides |
Pharmacological agents destructive to nematodes in the superfamily Filarioidea. |
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| D006166 |
Guatemala |
A country in CENTRAL AMERICA bordering the North Pacific Ocean, between EL SALVADOR and MEXICO, and bordering the Gulf of Honduras (Caribbean Sea) between HONDURAS and BELIZE. |
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| D006801 |
Humans |
Members of the species Homo sapiens. |
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man |
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| D014687 |
Venezuela |
A country in northern South America, bordering the Caribbean Sea and the North Atlantic Ocean, located between Colombia and Guyana. |
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| D015827 |
Onchocerciasis, Ocular |
Filarial infection of the eyes transmitted from person to person by bites of Onchocerca volvulus-infected black flies. The microfilariae of Onchocerca are thus deposited beneath the skin. They migrate through various tissues including the eye. Those persons infected have impaired vision and up to 20% are blind. The incidence of eye lesions has been reported to be as high as 30% in Central America and parts of Africa. |
River Blindness,Blindness, River,Ocular Onchocerciases,Ocular Onchocerciasis,Onchocerciases, Ocular |
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