Biomaterial Database

Positive inotropic and toxic action of direct lytic factor on isolated working guinea pig hearts. 1991

S J Huang, and C K Wu, and J J Sun

Department of Pharmacology, Sun Yat-Sen University of Medical Sciences, Guangzhou, China.

The positive inotropic and the toxic effects of direct lytic factor (DLF) on the isolated working guinea pig hearts were studied. As compared with baseline values, DLF 1-10 micrograms.ml-1 increased aortic flow up to 138% cardiac output 116%, left ventricular pressure volume work 136%, left ventricular pressure 114%, dP/dtmax 130%, Vmax 128%, and mean aortic systolic pressure 114%, but coronary flow was decreased by 16% on an average (n = 6). However, heart rate remained constant, myocardial oxygen consumption and efficiency were changed little. The cardiotonic effect of DLF was also observed by recording the isometric contractions of the isolated guinea pig papillary muscles and by determining the left ventricular pressure and dP/dtmax in anesthetized dogs. Neither spontaneously beating rate of right atrium nor the excitability of left atrium in vitro was affected by DLF. The results show that DLF is one of the cardiotonic agents without chronotropic effect and its coronary vasoconstriction effect plays an important part in heart failure.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009200	Myocardial Contraction	Contractile activity of the MYOCARDIUM.	Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D004179	Cobra Cardiotoxin Proteins	Most abundant proteins in COBRA venom; basic polypeptides of 57 to 62 amino acids with four disulfide bonds and a molecular weight of less than 7000; causes skeletal and cardiac muscle contraction, interferes with neuromuscular and ganglionic transmission, depolarizes nerve, muscle and blood cell membranes, thus causing hemolysis.	Cobra Cardiotoxin,Direct Lytic Factors,Cardiotoxin I,Cardiotoxin II,Cardiotoxin VII 4,Cardiotoxin VII2,Cardiotoxin-Like Basic Polypeptide,Cardiotoxins, Elapid,Cobra Cytotoxin Proteins,Cobra Toxin Gamma,Cobra Venom Cardiotoxin D,Cytotoxin-Like Basic Protein (Cobra Venom),Basic Polypeptide, Cardiotoxin-Like,Cardiotoxin Like Basic Polypeptide,Cardiotoxin Proteins, Cobra,Cardiotoxin, Cobra,Cytotoxin Proteins, Cobra,Elapid Cardiotoxins,Lytic Factors, Direct,Polypeptide, Cardiotoxin-Like Basic,Toxin Gamma, Cobra
D004546	Elapid Venoms	Venoms from snakes of the family Elapidae, including cobras, kraits, mambas, coral, tiger, and Australian snakes. The venoms contain polypeptide toxins of various kinds, cytolytic, hemolytic, and neurotoxic factors, but fewer enzymes than viper or crotalid venoms. Many of the toxins have been characterized.	Cobra Venoms,Elapidae Venom,Elapidae Venoms,Naja Venoms,Cobra Venom,Elapid Venom,Hydrophid Venom,Hydrophid Venoms,King Cobra Venom,Naja Venom,Ophiophagus hannah Venom,Sea Snake Venom,Sea Snake Venoms,Venom, Cobra,Venom, Elapid,Venom, Elapidae,Venom, Hydrophid,Venom, King Cobra,Venom, Naja,Venom, Ophiophagus hannah,Venom, Sea Snake,Venoms, Cobra,Venoms, Elapid,Venoms, Elapidae,Venoms, Hydrophid,Venoms, Naja,Venoms, Sea Snake
D005260	Female		Females
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006334	Heart Function Tests	Examinations used to diagnose and treat heart conditions.	Cardiac Function Tests,Cardiac Function Test,Function Test, Cardiac,Function Test, Heart,Function Tests, Cardiac,Function Tests, Heart,Heart Function Test,Test, Cardiac Function,Test, Heart Function,Tests, Cardiac Function,Tests, Heart Function
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013268	Stimulation, Chemical	The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.	Chemical Stimulation,Chemical Stimulations,Stimulations, Chemical
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In