BIOMAT Database Logo BIOMAT Database Logo

Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives. 2007

Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.

A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25 microg/ml.

UI MeSH Term Description Entries
D008745 Methylation Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed) Methylations
D009169 Mycobacterium tuberculosis A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation. Mycobacterium tuberculosis H37Rv
D009284 Naphthols Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications. Hydroxynaphthalene,Hydroxynaphthalenes,Naphthol
D000995 Antitubercular Agents Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. Anti-Tuberculosis Agent,Anti-Tuberculosis Agents,Anti-Tuberculosis Drug,Anti-Tuberculosis Drugs,Antitubercular Agent,Antitubercular Drug,Tuberculostatic Agent,Tuberculostatic Agents,Antitubercular Drugs,Agent, Anti-Tuberculosis,Agent, Antitubercular,Agent, Tuberculostatic,Anti Tuberculosis Agent,Anti Tuberculosis Agents,Anti Tuberculosis Drug,Anti Tuberculosis Drugs,Drug, Anti-Tuberculosis,Drug, Antitubercular
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D015195 Drug Design The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include PHARMACOKINETICS, dosage analysis, or drug administration analysis. Computer-Aided Drug Design,Computerized Drug Design,Drug Modeling,Pharmaceutical Design,Computer Aided Drug Design,Computer-Aided Drug Designs,Computerized Drug Designs,Design, Pharmaceutical,Drug Design, Computer-Aided,Drug Design, Computerized,Drug Designs,Drug Modelings,Pharmaceutical Designs
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular

Related Publications

Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Design, Synthesis, and in vitro antitubercular activity of 1,2,3-triazolyl-dihydroquinoline derivatives.
July 2018, Chemical biology & drug design,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity.
June 2014, European journal of medicinal chemistry,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity.
September 2017, European journal of medicinal chemistry,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Synthesis and antitubercular activity of novel amino acid derivatives.
February 2012, Chemical biology & drug design,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives.
December 2010, European journal of medicinal chemistry,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Synthesis and antitubercular activity of substituted novel pyrazoline derivatives.
June 2007, Natural product research,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Design and synthesis of novel pyrimidine derivatives as potent antitubercular agents.
February 2019, European journal of medicinal chemistry,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives.
January 2019, Monatshefte fur chemie,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives.
March 2007, Bioorganic & medicinal chemistry letters,
Sajal Kumar Das, and Gautam Panda, and Vinita Chaturvedi, and Y S Manju, and Anil K Gaikwad, and Sudhir Sinha
Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives.
October 2007, Bioorganic & medicinal chemistry letters,
Copied contents to your clipboard!