BIOMAT Database Logo BIOMAT Database Logo

Lithium clearance in patients with chronic renal failure. 1991

N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
First and Second Faculty of Medicine, Faculty of Sciences, University Federico II, Naples, Italy.

Lithium clearance (CLi) was studied in the healthy subjects (H) and in patients with chronic renal failure (CRF) with a mean GFR of 36.08 +/- 3.8 ml/min x 1.73 m2 in order to evaluate (1) the variability of CLi measurements; (2) the changes of CLi during the hyperfiltration response to a meat meal (2 g/kg b.w. of protein), and (3) the effects on CLi of different protein intakes. CLi correlated with GFR and with urinary sodium, FeLi correlated with FeNa in H and CRF. The intraindividual standard deviation (IISD) of GRF, CLi and FeLi assessed in triplicate studies in the course of a single experiment averaged 4.70, 7.15 and 10.69% in CRF and 1.77, 4.09 and 4.61% in H. When IISD for GFR, CLi, and FeLi was assessed in triplicate measurements in the course of 3 studies performed at 1-week intervals (day 1, day 8, day 15), it averaged 7.36, 9.21 and 15.72% in CRF and 1.83, 5.08 and 5% in H. During the hyperfiltration response to a meat meal, CLi and FeLi did not change in CRF and increased significantly in H. In 10 patients with CRF who were switched for 3 weeks from a protein intake of 0.85 g/kg to a protein intake of 0.60 g/kg, GFR was significantly (p less than 0.001) reduced by 29%, while CLi was stable. The data indicate that because of its variability, CLi is of little use in experiments designed to study subtle changes in renal Na transport.

UI MeSH Term Description Entries
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008094 Lithium An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER. Lithium-7,Lithium 7
D008297 Male Males
D008460 Meat The edible portions of any animal used for food including cattle, swine, goats/sheep, poultry, fish, shellfish, and game. Meats
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D004044 Dietary Proteins Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS. Proteins, Dietary,Dietary Protein,Protein, Dietary
D005260 Female Females
D005919 Glomerular Filtration Rate The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance. Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
Lithium clearance in patients with chronic renal diseases.
December 1991, Clinical nephrology,
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
Low-density lipoprotein clearance in patients with chronic renal failure.
July 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
Renal clearance of amino acids in patients with severe chronic renal failure.
January 1978, Nephron,
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
Decreased clearance of low-density lipoprotein in patients with chronic renal failure.
February 1994, Kidney international,
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
[Renal lithium clearance].
January 1993, Nephrologie,
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
[Salivary and pancreatic amylase clearance to creatinine clearance ratios in patients with chronic renal failure (author's transl)].
February 1980, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
Mucociliary clearance in patients with chronic autonomic failure.
September 1980, Thorax,
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
[Validity of iohexol clearance in patients with chronic renal failure and normal renal function in comparison to (99m)Tc-DTPA-clearance].
January 2003, Deutsche medizinische Wochenschrift (1946),
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
Middle molecules in patients with pre-dialysis chronic renal failure: a comparative clearance study.
April 1982, Clinical nephrology,
N G DeSanto, and S Coppola, and P Anastasio, and G Coscarella, and G Capasso, and R Santangelo, and L Bellini, and G Spagnuolo, and R Alfieri, and A Lombardi
Lithium in chronic renal failure: a case report.
January 2010, General hospital psychiatry,
Copied contents to your clipboard!