-transparent.png){kind=logo}
Exposure to light of Chinese hamster cells preloaded with chloroaluminum phthalocyanine causes an immediate increase of cytoplasmic free calcium, [Ca2+], from about 0.2 microM to 1 microM within 5 min after illumination. This increase was dose-dependent within the biological dose range, reaching a plateau at a dose that kills 99.5% of the cells. Fluoride addition prior to light exposure protected against cell killing and reduced the increase of [Ca2+]i. These findings raise the possibility that changes in [Ca2+]i after photodynamic treatment may be relevant to cell killing and/or other biological responses of the cells, e.g. release of eicosanoids.
Related Publications
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
February 1992,
Photochemistry and photobiology,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
July 1983,
Photochemistry and photobiology,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
April 1979,
Experimental cell research,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
March 1998,
Proceedings of the National Academy of Sciences of the United States of America,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
September 1988,
Photochemistry and photobiology,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
September 1980,
The Journal of cell biology,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
February 1985,
Photochemistry and photobiology,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
December 1987,
The Journal of endocrinology,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
September 1989,
Proceedings of the National Academy of Sciences of the United States of America,
E Ben-Hur, and
T M Dubbelman, and
J Van Steveninck
August 1986,
The Journal of physiology,
