BIOMAT Database Logo BIOMAT Database Logo

A case of insulin-secreting tumor successfully treated with diazoxide. 1991

H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
Department of Internal Medicine, School of Medicine, Tokai University, Kanagawa, Japan.

A 72-year-old patient was referred to our hospital because of a hypoglycemic crisis possibly due to an insulin secreting-tumor. Although its localization was assumed to be at the head of the pancreas as assessed by transhepatic venography with sampling, no mass lesion was detected by selective angiography, ultrasound, computerized axial tomography, magnetic resonance imaging and 67Ga-citrate scan. The patient was treated with diazoxide, because of poor localization and his age, insulin secretion was improved after both 30 and 60 min in the 75 g oral glucose tolerance test. The total amount of urinary C-peptide excretion decreased from 70.8 to 29.2 mcg/day. Thereafter, no hypoglycemic symptoms were observed during his admission. No side effects except mild liver damage were observed.

UI MeSH Term Description Entries
D007003 Hypoglycemia A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH. Fasting Hypoglycemia,Postabsorptive Hypoglycemia,Postprandial Hypoglycemia,Reactive Hypoglycemia,Hypoglycemia, Fasting,Hypoglycemia, Postabsorptive,Hypoglycemia, Postprandial,Hypoglycemia, Reactive
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007340 Insulinoma A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA. Adenoma, beta-Cell,Insuloma,beta-Cell Tumor,Adenoma, beta Cell,Adenomas, beta-Cell,Insulinomas,Insulomas,Tumor, beta-Cell,Tumors, beta-Cell,beta Cell Tumor,beta-Cell Adenoma,beta-Cell Adenomas,beta-Cell Tumors
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D010190 Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA). Cancer of Pancreas,Pancreatic Cancer,Cancer of the Pancreas,Neoplasms, Pancreatic,Pancreas Cancer,Pancreas Neoplasms,Pancreatic Acinar Carcinoma,Pancreatic Carcinoma,Acinar Carcinoma, Pancreatic,Acinar Carcinomas, Pancreatic,Cancer, Pancreas,Cancer, Pancreatic,Cancers, Pancreas,Cancers, Pancreatic,Carcinoma, Pancreatic,Carcinoma, Pancreatic Acinar,Carcinomas, Pancreatic,Carcinomas, Pancreatic Acinar,Neoplasm, Pancreas,Neoplasm, Pancreatic,Neoplasms, Pancreas,Pancreas Cancers,Pancreas Neoplasm,Pancreatic Acinar Carcinomas,Pancreatic Cancers,Pancreatic Carcinomas,Pancreatic Neoplasm
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003981 Diazoxide A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. Hyperstat,Proglycem
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
A rare case of adult-onset nesidioblastosis treated successfully with diazoxide.
February 2006, Endocrine journal,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
[Case Report; A case of geriatric insulinoma successfully treated by diazoxide].
November 2014, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
[Diazoxide in essential hypertension. Apropos of a case successfully treated].
November 1973, Revista clinica espanola,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
[Infant idiopathic hypoglycemia treated successfully with diazoxide].
June 1983, Horumon to rinsho. Clinical endocrinology,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
[A recurrent case of lipid-secreting carcinoma of the breast successfully treated with capecitabine].
September 2008, Gan to kagaku ryoho. Cancer & chemotherapy,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
[Successfully treated case of urachus tumor].
June 1971, Geka chiryo. Surgical therapy,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
[Insulin secreting islet cell carcinoma treated with streptozotocin (apropose of a case)].
January 1976, Medecine & chirurgie digestives,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
Insulin resistance in a diabetic child. Report of a case successfully treated with pork insulin.
January 1962, Diabetes,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
A case of recurrent malignant triton tumor successfully treated with radiotherapy.
December 2016, Auris, nasus, larynx,
H Takeda, and K Watanabe, and D Suzuki, and R Miyano, and K Tanaka, and H Machimura, and M Yagame, and W Inoue, and H Kaneshige, and H Sakai
[Successfully treated case of primary diaphragmatic tumor].
December 1968, Kyobu geka. The Japanese journal of thoracic surgery,
Copied contents to your clipboard!