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The effect of phosphoenolpyruvate (PEP) on energy metabolism of ischemic liver was examined in anesthetized rats. In vivo 31P-NMR spectroscopy (31P-MRS) was used to monitor cellular energy metabolism. Hepatic ischemia was induced by temporarily clamping the portal vein for 60 minutes. The liver adenosine triphosphate (ATP) levels decreased remarkably during ischemia, and they gradually increased after ischemia but did not return to pre-operative levels. PEP effectively increased the levels of ATP. The ATP levels of the PEP-treated rats were significantly higher than those of the control rats, and also intracellular acidosis was improved during post-ischemic reperfusion. These findings suggest that PEP may have a cytoprotective effect and improve the energy metabolism in the ischemic liver.
K Matsui, and
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March 1988,
Biochemical and biophysical research communications,
K Matsui, and
M Kojima
March 1988,
Biochemical and biophysical research communications,
K Matsui, and
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January 2004,
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K Matsui, and
M Kojima
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K Matsui, and
M Kojima
November 1993,
Masui. The Japanese journal of anesthesiology,
K Matsui, and
M Kojima
February 1988,
Biochemical and biophysical research communications,
K Matsui, and
M Kojima
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Zhonghua yi xue za zhi,
K Matsui, and
M Kojima
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Magma (New York, N.Y.),
K Matsui, and
M Kojima
June 1998,
Journal of applied physiology (Bethesda, Md. : 1985),
K Matsui, and
M Kojima
April 1992,
Medicine and science in sports and exercise,
