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The authors have studied genotoxicological effects of MMC by means of CB- and C-MNT to evaluate practical value of CB-MNT. The main results are as follows: (1) In 0.025-0.4 microgram/ml of MMC MNFs in lymphocytes detected by CB- and C-MNT presented dose-dependent increase, but the MNT detected by C-MNT was higher than that by CB-MNT, this difference became greater as MMC concentrations were increased. The minimum concentrations were 0.1 microgram/ml for CB-MNT and 0.025 microgram/ml for C-MNT respectively. Therefore C-MNT is more sensitive to MMC than to CB-MNT; (2) The mean volume of MN detected by CB- and C-MNT was estimated separately. The volume of MN detected by CB-MNT was about 3 times as large as that by C-MNT. The authors suggested that the fusion between micronuclei in cytoplasm of CB- cells could lead to increase of MN volume and decrease of MN numbers; (3) In healthy donors the background MNF in lymphocytes detected by CB-MNT was significantly higher than that by C-MNT, it could be one of the reasons that led to the decrease of the sensitivity of CB-MNT to low doses of mutagens. Finally, the practical value of CB- and C-MNT was discussed.
K X Xue, and
Z L Shen, and
G J Ma
March 2000,
Mutagenesis,
K X Xue, and
Z L Shen, and
G J Ma
November 2012,
Mutagenesis,
K X Xue, and
Z L Shen, and
G J Ma
January 2007,
Journal of applied toxicology : JAT,
K X Xue, and
Z L Shen, and
G J Ma
January 2011,
Methods in molecular biology (Clifton, N.J.),
K X Xue, and
Z L Shen, and
G J Ma
January 2006,
Drug and chemical toxicology,
K X Xue, and
Z L Shen, and
G J Ma
November 2003,
Journal of occupational health,
K X Xue, and
Z L Shen, and
G J Ma
August 1988,
Die Pharmazie,
K X Xue, and
Z L Shen, and
G J Ma
May 2018,
Toxicology and industrial health,
K X Xue, and
Z L Shen, and
G J Ma
July 1996,
Environmental health and preventive medicine,
K X Xue, and
Z L Shen, and
G J Ma
March 2014,
DNA and cell biology,
