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Phase II study of teniposide in patients with AIDS-related Kaposi's sarcoma. 1991
G Schwartsmann, and
E Sprinz, and
M Kronfeld, and
J Vinholes, and
E Sander, and
M Zampese, and
R Preger, and
L Kalakun, and
A L Brunetto
AIDS and Oncology Unit, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
Antitumour activity of cytotoxic agents, evaluated in patients with AIDS-related Kaposi's sarcoma (KS), is about 30-80%. However, responses are mostly partial and short. Experience with etoposide is similar. Teniposide has a longer elimination half-life and superior antitumour activity compared with etoposide in some experimental models. Thus a phase II trial was done in 25 patients with AIDS-related KS. Teniposide was given by 60-min infusion at 360 mg/m2 every 3 weeks. 10 (40%) showed a partial response, median duration of 9 (6-20) weeks. The main side-effects were leukopenia, thrombocytopenia, nausea and vomiting, alopecia and mucositis.
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E Sprinz, and
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E Sander, and
M Zampese, and
R Preger, and
L Kalakun, and
A L Brunetto
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