Baroreflex dysfunction in rats submitted to protein restriction. 2007

Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
Department of Biological Sciences, DECBI-NUPEB, Federal University of Ouro Preto, 35400-000, Ouro Preto, MG, Brazil.

Earlier studies from the authors' laboratory showed that malnourishment induces alterations in the cardiovascular homeostasis increasing the basal mean arterial pressure and heart rate. In this study, the authors evaluated whether the sympathetic and parasympathetic efferent activities contribute to changes in the cardiovascular homeostasis through altered modulation of the arterial baroreflex of malnourished rats. After weaning, male Fischer rats were given 15% (Normal Protein--NP) or 6% (Low Protein--LP) protein diet for 35 d. The baroreflex gain and latency were evaluated before and after selective autonomic blockades in control and malnourished rats. It was observed that malnourishment affected the baroreflex gain in response to activation and deactivation of the arterial baroreflex. Moreover, malnourished rats showed increased baroreflex latency as compared to that of control rats. Regarding the autonomic efferent activity directed to the heart, the data showed increased sympathetic and decreased parasympathetic efferent activities in malnourished rats, and such alterations could be related to the observed changes in the arterial baroreflex gain as well as in the basal mean arterial pressure and heart rate.

UI MeSH Term Description Entries
D008297 Male Males
D008790 Metoprolol A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS. Beloc-Duriles,Betaloc,Betaloc-Astra,Betalok,CGP-2175,H 93-26,Lopressor,Metoprolol CR-XL,Metoprolol Succinate,Metoprolol Tartrate,Seloken,Spesicor,Spesikor,Toprol,Toprol-XL,Beloc Duriles,Betaloc Astra,CGP 2175,CGP2175,H 93 26,H 9326,Metoprolol CR XL,Toprol XL
D011312 Pressure A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Pressures
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D011916 Rats, Inbred F344 An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes. Fischer Rats,Rats, Inbred CDF,Rats, Inbred Fischer 344,Rats, F344,Rats, Inbred Fisher 344,CDF Rat, Inbred,CDF Rats, Inbred,F344 Rat,F344 Rat, Inbred,F344 Rats,F344 Rats, Inbred,Inbred CDF Rat,Inbred CDF Rats,Inbred F344 Rat,Inbred F344 Rats,Rat, F344,Rat, Inbred CDF,Rat, Inbred F344,Rats, Fischer
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001158 Arteries The vessels carrying blood away from the heart. Artery

Related Publications

Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
June 2012, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
January 2003, Research communications in molecular pathology and pharmacology,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
February 2005, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
February 2011, Clinical and experimental pharmacology & physiology,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
September 2009, Experimental physiology,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
April 2002, American journal of physiology. Heart and circulatory physiology,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
November 2005, Atherosclerosis,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
September 2008, Journal of pharmacological sciences,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
January 1997, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
Igor de O Loss, and Luciano G Fernandes, and Carlito D D Martins, and Leonardo M Cardoso, and Marcelo E Silva, and Valdo J Dias-da-Silva, and Márcio F D Moraes, and Deoclécio A Chianca
May 2006, Nutrition (Burbank, Los Angeles County, Calif.),
Copied contents to your clipboard!