-transparent.png){kind=logo}
Various amounts of the bacterium, Brucella abortus (BA) were injected intravenously into autoimmune NZB/W F1 mice and non-autoimmune BDF1 mice and then the localization of BA in the thymus was traced using an immunohistochemical method at 30 min and 3 h after injection. The results showed that a greater amount of BA became consistently localized in the thymic parenchyma in a free form or in a phagocytized form in NZB/W F1 mice in comparison with BDF1 mice, indicating a marked increase of vascular permeability in the thymus of NZB/W F1 mice. The extravascular leakage of BA was clearly dose-dependent. The significance of invasion of bacterial antigens from the general circulation into the thymic parenchyma is discussed in relation to autoimmune states.
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
January 1992,
Autoimmunity,
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
November 1973,
Clinical immunology and immunopathology,
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
December 1990,
Clinical and experimental immunology,
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
November 2013,
Immunobiology,
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
November 1971,
Arerugi = [Allergy],
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
April 2011,
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine,
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
March 1988,
Journal of clinical & laboratory immunology,
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
October 2003,
Clinical and experimental immunology,
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
December 1991,
Clinical immunology and immunopathology,
J Ohmori, and
K Miyakawa, and
K Matsuno, and
M Kotani
April 2008,
Lupus,
